Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50019845
TargetKynurenine 3-monooxygenase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50266036(CHEMBL4092205)
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged recombinant human KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50386292(CHEMBL2047851)
Affinity DataIC50: 23nMAssay Description:Inhibition of Kynurenine aminotransferase II (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50623699(CHEMBL5416308)
Affinity DataIC50: 24nMAssay Description:Inhibition of rat liver KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of rat kidney KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50623700(CHEMBL5433358)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat liver KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50623698(CHEMBL5430817)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat brain KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50061915(CHEMBL554000 | CHEMBL139909 | 2-Amino-4-(3,4-dichl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of rat brain KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623696(CHEMBL5429250)
Affinity DataIC50: 315nMAssay Description:Inhibition of human recombinant KATIIMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50289137(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataIC50: 492nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM273011((R)-2-{6-methyl-5-[(morpholin-4-yl)methyl]-7-oxo-6...)
Affinity DataIC50: 610nMAssay Description:Inhibition of His-tagged recombinant human KATIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50623697(CHEMBL2040644)
Affinity DataIC50: 900nMAssay Description:Inhibition of human recombinant KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50088520(CHEMBL3526575)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50126148(CHEMBL3629572)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of rat KATIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50623701(CHEMBL5397926)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of rat liver KMOMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50030257(CHEBI:67862 | COPTISINE)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human recombinant IDO1 expressed in Escherichia coli BL21 incubated for 6 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623695(CHEMBL5395137)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of KATII in rat liver homogenateMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623695(CHEMBL5395137)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of Kynurenine aminotransferase II (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50623699(CHEMBL5416308)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of His-tagged recombinant human KMO using diclofenac as substrateMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM21973(2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid |...)
Affinity DataIC50: 3.80E+5nMAssay Description:Inhibition of human recombinant IDO1 expressed in Escherichia coli BL21 incubated for 6 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50289137(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataKi:  51nMAssay Description:Binding affinity to IDO (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynureninase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50109155(2-amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic aci...)
Affinity DataKi:  100nMAssay Description:Binding affinity to human recombinant Kynureninase assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynureninase(Rat)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50109155(2-amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic aci...)
Affinity DataKi:  130nMAssay Description:Binding affinity to rat Kynureninase assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed