Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50019248
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM557265(US11352354, Example V-c-17)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to PIKFYVE (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM60996(MLS002153482 | Aurintricarboxylic acid | 5-[(3-car...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of SARS-CoV-1 RdRp-mediated viral replicationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | benzyl (S)-3-methyl-1-oxo-1-((S)-1-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human CTSL-mediated substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SARS-CoV-1 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50590927(Apilimod | Sta-5326 | STA 5326 | STA-5326 | APILIM...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50598463(CHEMBL5195325)
Affinity DataIC50: 15nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50405464(CHEMBL5270743)
Affinity DataIC50: 17nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM476972(SARS-CoV-2 3CLP and CoV inhibitor 15l)
Affinity DataIC50: 19nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50617129(CHEMBL5076204)
Affinity DataIC50: 34nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 53nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50617130(CHEMBL5404684)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant cathepsin L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM429242(jm5b01461, Compound 59 | acs.jmedchem.1c00409_ST.4)
Affinity DataIC50: 740nMAssay Description:Inhibition of SARS-CoV-1 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 900nMAssay Description:Inhibition of SARS-CoV-1 MProMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 900nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50016900(CINANSERIN | CHEMBL18786 | N-(2-(3-(dimethylamino)...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SARS-CoV 3CLproMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50016900(CINANSERIN | CHEMBL18786 | N-(2-(3-(dimethylamino)...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of SARS-CoV-1 RdRp-mediated viral replicationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of SARS-CoV-1 MProMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataKi:  0.270nMAssay Description:Binding affinity to SARS-CoV-2 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to SARS-CoV-2 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to SARS-CoV-1 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM429242(jm5b01461, Compound 59 | acs.jmedchem.1c00409_ST.4)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to SARS-CoV-2 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM429242(jm5b01461, Compound 59 | acs.jmedchem.1c00409_ST.4)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to SARS-CoV-1 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM59242(Benzotriazole ester, 8 | med.21724, Compound 91 | ...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to SARS-CoV-1 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM429100(jm5b01461, Compound 45 | MPI8)
Affinity DataKi:  53nMAssay Description:Binding affinity to SARS-CoV-1 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Siena

Curated by ChEMBL
LigandPNGBDBM419120(the N3 Compound | cmdc.202100576, 8d(N3) | acs.jme...)
Affinity DataKi:  9.00E+3nMAssay Description:Binding affinity to SARS-CoV-1 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed