Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50019828
TargetPolycomb protein EED(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50563659(CHEMBL4759335)
Affinity DataKd:  0.5nMAssay Description:Inhibition of EED (unknown origin) assessed dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolycomb protein EED(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM291687(US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataKd:  0.400nMAssay Description:Inhibition of EED (unknown origin) assessed dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623413(CHEMBL5427321)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant GCN2 using eIF2alpha as substrateMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPolycomb protein EED(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM291687(US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 5nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623412(CHEMBL5393957)
Affinity DataIC50: 16nMAssay Description:Inhibition of human GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623414(CHEMBL5437361)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant GCN2 by P-ATP kinase assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPolycomb protein EED(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: 30nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50407800(CHEMBL5291138)
Affinity DataIC50: 49nMAssay Description:Inhibition of LSD1 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolycomb protein EED(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50563659(CHEMBL4759335)
Affinity DataIC50: 50nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50: 120nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 5(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623411(CHEMBL5439539)
Affinity DataIC50: 300nMAssay Description:Inhibition of human GCN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetCyclin-dependent kinase 1(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 650nMAssay Description:Inhibition of CDC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623410(CHEMBL5169329)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of USP28 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPaired box protein Pax-2(Homo sapiens)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623409(CHEMBL5414180)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of pax2 (unknown origin) in human SK-OV-3 cells measured after 24 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50594622(CHEMBL4865857)
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of human BRD4 BD1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolycomb protein EED(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50236003(CHEMBL4096234)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50594622(CHEMBL4865857)
Affinity DataIC50: 4.36E+3nMAssay Description:Inhibition of human BRD4 BD2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623410(CHEMBL5169329)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of USP7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50623410(CHEMBL5169329)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhenzhou University

Curated by ChEMBL
LigandPNGBDBM50407800(CHEMBL5291138)
Affinity DataKi:  16nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed