Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50019821
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataKd:  798nMAssay Description:Binding affinity to CM5 chip-immobilised full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells assessed as d...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataIC50: 78nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 118nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623329(CHEMBL5418476)
Affinity DataIC50: 124nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623330(CHEMBL162755)
Affinity DataIC50: 136nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623327(CHEMBL5435359)
Affinity DataIC50: 143nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623331(CHEMBL351694)
Affinity DataIC50: 165nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 191nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 193nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 206nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623336(CHEMBL5430129)
Affinity DataIC50: 252nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 302nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623328(CHEMBL5433491)
Affinity DataIC50: 323nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623333(CHEMBL5441037)
Affinity DataIC50: 373nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 409nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 448nMAssay Description:Inhibition of SARS-CoV-2 PLpro using RLRGG-AMC substrate preincubated for 30 mins followed by substrate addition measured for 5 mins by fluorescence ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623335(CHEMBL5408081)
Affinity DataIC50: 462nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623334(CHEMBL5408402)
Affinity DataIC50: 582nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 655nMAssay Description:Inhibition of SARS-CoV-2 PLpro using RLRGG-AMC substrate preincubated for 30 mins followed by substrate addition measured for 5 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623326(CHEMBL1431798)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of full-length recombinant SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using fluorogenic MCA-AVLQSGFR-Lys (Dnp)...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetCathepsin B(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin B using Z-RR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 10 mins by FRET assa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCathepsin B(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin B using Z-RR-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 10 mins by FRET assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetChymotrypsinogen B2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of chymotrypsin (unknown origin) using N-succinyl-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetChymotrypsinogen B2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of chymotrypsin (unknown origin) using N-succinyl-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin L using Z-VVR-AMC as substrate measured for 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50623332(CHEMBL5423593)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin L using Z-VVR-AMC as substrate measured for 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed