Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50019343
TargetApoptosis regulator BAX(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50547480(CHEMBL4790235)
Affinity DataIC50: 247nMAssay Description:Displacement of FITC-labeled BIM SAHBA2 from human full length BAX trigger site expressed in Escherichia coli measured for 20 mins by competitive flu...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C9(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50547480(CHEMBL4790235)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate prewarmed for 10 mins followed by NADPH addition and measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetApoptosis regulator BAX(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50078015(CHEMBL3417395)
Affinity DataIC50: 3.31E+3nMAssay Description:Displacement of FITC-labeled BIM SAHB from recombinant BAX (unknown origin) measured for 20 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 1A2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50547480(CHEMBL4790235)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate prewarmed for 10 mins followed by NADPH addition and measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50547480(CHEMBL4790235)
Affinity DataIC50: 2.95E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate prewarmed for 10 mins followed by NADPH addition and measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 1A2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618287(CHEMBL5422432)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate prewarmed for 10 mins followed by NADPH addition and measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C9(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618287(CHEMBL5422432)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate prewarmed for 10 mins followed by NADPH addition and measured after 10 m...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C19(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50547480(CHEMBL4790235)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate prewarmed for 10 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C19(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618287(CHEMBL5422432)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate prewarmed for 10 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2D6(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50547480(CHEMBL4790235)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate prewarmed for 10 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2D6(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618287(CHEMBL5422432)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate prewarmed for 10 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50618287(CHEMBL5422432)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate prewarmed for 10 mins followed by NADPH addition and measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails
PubMed