Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50019278
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617536(CHEMBL5408616)
Affinity DataKd:  1.06E+3nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617532(CHEMBL5410925)
Affinity DataKd:  1nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617533(CHEMBL5403382)
Affinity DataKd:  1nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  11nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataKd:  8.20nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  170nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50004205(MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...)
Affinity DataKd:  290nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  3.50E+3nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  5.30E+3nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  200nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  900nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  48nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1.20nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  66nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50389803(CHEMBL2041933 | AZD7762)
Affinity DataKd:  37nMAssay Description:Binding affinity of AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311199(US10155760, Example 43 | (S)-2,4-dimethyl-1-(4-(py...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573689(CHEMBL4857123)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant AAK1 expressed in human HEK293F cells co-expressed with AP-2 assessed as reduction in AP-2 phosphorylation by western blott...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573689(CHEMBL4857123)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant AAK1 (unknown origin) expressed in baculovirus assessed as reduction in AP-2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617535(CHEMBL5431686)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant AAK1 (unknown origin) expressed in baculovirus assessed as reduction in AP-2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of AAK1 expressed in human HEK293K cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573688(CHEMBL4127773)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant AAK1 expressed in human HEK293F cells co-expressed with AP-2 assessed as reduction in AP-2 phosphorylation by western blott...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617534(CHEMBL5426721)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of GST-Xa-tagged recombinant human AAK1 using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 as substrate assessed as reduction in AP2M1 phosphorylati...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311199(US10155760, Example 43 | (S)-2,4-dimethyl-1-(4-(py...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of AAK1 expressed in human HEK293K cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617535(CHEMBL5431686)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant AAK1 expressed in human HEK293F cells co-expressed with AP-2 assessed as reduction in AP-2 phosphorylation by western blott...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573688(CHEMBL4127773)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant AAK1 (unknown origin) expressed in baculovirus assessed as reduction in AP-2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603680(CHEMBL5194899)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573690(CHEMBL4855590)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant AAK1 (unknown origin) expressed in baculovirus assessed as reduction in AP-2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50502285(CHEMBL4543869)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573690(CHEMBL4855590)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of recombinant AAK1 expressed in human HEK293F cells co-expressed with AP-2 assessed as reduction in AP-2 phosphorylation by western blott...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617537(CHEMBL5416533)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged recombinant AAK1 (unknown origin) using AP2M1 peptide as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617533(CHEMBL5403382)
Affinity DataIC50: 10nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617532(CHEMBL5410925)
Affinity DataIC50: 10nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573686(CHEMBL4877470)
Affinity DataIC50: 15nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603674(CHEMBL5205801)
Affinity DataIC50: 16nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603669(CHEMBL5175828)
Affinity DataIC50: 17nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603679(CHEMBL5204563)
Affinity DataIC50: 22nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603661(CHEMBL5208293)
Affinity DataIC50: 30nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50617538(CHEMBL5435401)
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged recombinant AAK1 (unknown origin) using AP2M1 peptide as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50586141(CHEMBL5079068)
Affinity DataIC50: 48nMAssay Description:Inhibition of AAK1 expressed in human HEK293K cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50586141(CHEMBL5079068)
Affinity DataIC50: 49nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603660(CHEMBL5182634)
Affinity DataIC50: 67nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50573678(CHEMBL4862414)
Affinity DataIC50: 170nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603662(CHEMBL5177481)
Affinity DataIC50: 220nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM8375(N-[6-(3-methanesulfonamidophenyl)-1H-indazol-3-yl]...)
Affinity DataIC50: 220nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50603659(CHEMBL5172186)
Affinity DataIC50: 420nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311199(US10155760, Example 43 | (S)-2,4-dimethyl-1-(4-(py...)
Affinity DataIC50: 630nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM50586141(CHEMBL5079068)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
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