Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50019171
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616113(CHEMBL5417139)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616115(CHEMBL5407530)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616107(CHEMBL5432826)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616112(CHEMBL5400234)
Affinity DataIC50: 2nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616111(CHEMBL5403199)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 10nMAssay Description:Inhibition of Mer (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616115(CHEMBL5407530)
Affinity DataIC50: 17nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616109(CHEMBL5420397)
Affinity DataIC50: 18nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 19nMAssay Description:Inhibition of TrkA (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 20nMAssay Description:Inhibition of TAO1 (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 22nMAssay Description:Inhibition of KHS (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616113(CHEMBL5417139)
Affinity DataIC50: 28nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 38nMAssay Description:Inhibition of RSE (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616108(CHEMBL5432432)
Affinity DataIC50: 41nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 47nMAssay Description:Inhibition of CLK2 (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616111(CHEMBL5403199)
Affinity DataIC50: 54nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616110(CHEMBL5423834)
Affinity DataIC50: 60nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 64nMAssay Description:Inhibition of IRAK4 (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616112(CHEMBL5400234)
Affinity DataIC50: 67nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 81nMAssay Description:Inhibition of GLK (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 81nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 100nMAssay Description:Inhibition of HGK (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMisshapen-like kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 100nMAssay Description:Inhibition of MINK (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 117nMAssay Description:Inhibition of GCK (unknown origin) by Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616107(CHEMBL5432826)
Affinity DataIC50: 127nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 143nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 300nMAssay Description:Inhibition of HPK1 in human PBMC cells assessed as inhibition of SLP76 phosphorylation incubated for 4 hr by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616106(CHEMBL5409588)
Affinity DataIC50: 365nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 600nMAssay Description:Inhibition of HPK1 in human PBMC cells assessed as inhibition of SLP76 phosphorylation incubated for 4 hr by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50616114(CHEMBL5409039)
Affinity DataIC50: 3.46E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed