Compile Data Set for Download or QSAR
Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 50019165
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50616052(CHEMBL5419693)
Affinity DataKd:  7.78E+3nMAssay Description:Inhibition of human LSD1-CoREST expressed in Escherichia coli assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKd:  2.43E+5nMAssay Description:Inhibition of human LSD1-CoREST expressed in Escherichia coli assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM283216(US9573930, Example 86 | US10023543, Example 86 | 4...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50155773(US9469597, 5 | CHEMBL3781751)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50594947(VAFIDEMSTAT | Vafidemstat | ORY-2001)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50153586(CHEMBL3775474 | US10053456, 120 | US9718814, 71 | ...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM425083(US10519118, Example 158 | N-((S)-5-((1R,2S)-2-(4- ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50590443(Seclidemstat | Sp-2577 | SP-2577 | SP2577 | SECLID...)
Affinity DataIC50: 13nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50616051(CHEMBL5417619)
Affinity DataIC50: 18nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50403543(CHEMBL5276713)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human LSD1/CoREST by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataIC50: 870nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346866(CHEMBL1797643 | S1201)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of hexahistidine-tagged LSD1 (unknown origin) (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346865(CHEMBL1797642 | 2-PFPA)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of hexahistidine-tagged LSD1 (unknown origin) (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50590443(Seclidemstat | Sp-2577 | SP-2577 | SP2577 | SECLID...)
Affinity DataKi:  31nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM113742(N-[4-(2-Hydrazinylethyl)phenyl]-4-phenylbutanamide...)
Affinity DataKi:  59nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM113742(N-[4-(2-Hydrazinylethyl)phenyl]-4-phenylbutanamide...)
Affinity DataKi:  59nMAssay Description:Inhibition of GST tagged LSD1 (unknown origin) expressed in Escherichia coli using dimethyl-Lys-4 H3-21 peptide as substrate assessed as inhibition c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50616049(CHEMBL5438431)
Affinity DataKi:  193nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi:  370nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50507295(CHEMBL1232432)
Affinity DataKi:  440nMAssay Description:Inhibition of human LSD1-CoREST expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50568521(CHEMBL4878787)
Affinity DataKi:  560nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  610nMAssay Description:Inhibition of hexahistidine-tagged LSD1 (unknown origin) (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346589(CHEMBL255520 | CHEMBL1795974)
Affinity DataKi:  700nMAssay Description:Inhibition of human recombinant MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate by peroxidase-coupl...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346863(CHEMBL1797640 | US8765820, 5b)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human recombinant LSD1/CoREST expressed in Escherichia coli using Lys4 monomethylated histone H3 peptide as substrate assessed as inhib...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346864(CHEMBL1797641 | CHEMBL3104337 | US8765820, 8)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity to human recombinant MAO-A expressed in Pichia pastoris assessed as inhibition constant using kynuramine as substrate by peroxidase-...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346864(CHEMBL1797641 | CHEMBL3104337 | US8765820, 8)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human recombinant LSD1/CoREST expressed in Escherichia coli using Lys4 monomethylated histone H3 peptide as substrate assessed as inhib...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50616048(CHEMBL5403548)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50616053(CHEMBL5415714)
Affinity DataKi:  2.30E+3nMAssay Description:Reversible inhibition of 6-his tagged LSD1 (172 to 833 residues) (unknown origin) expressed in Escherichia coli Rosetta 2/6-his tagged CoREST1 (308 t...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346863(CHEMBL1797640 | US8765820, 5b)
Affinity DataKi:  2.30E+3nMAssay Description:Binding affinity to human recombinant MAO-A expressed in Pichia pastoris assessed as inhibition constant using kynuramine as substrate by peroxidase-...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50616050(CHEMBL5439284)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate by peroxidase-coupl...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346866(CHEMBL1797643 | S1201)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of hexahistidine-tagged LSD1 (unknown origin) (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346863(CHEMBL1797640 | US8765820, 5b)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate by peroxidase-coupl...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | trans-2-phe...)
Affinity DataKi:  4.40E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate by peroxidase-coupl...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of human recombinant MAO-A using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50105417(CHEMBL1089 | Nardil | Phenethyl-hydrazine | PHENEL...)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of GST tagged LSD1 (unknown origin) expressed in Escherichia coli using dimethyl-Lys-4 H3-21 peptide as substrate assessed as inhibition c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50105417(CHEMBL1089 | Nardil | Phenethyl-hydrazine | PHENEL...)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of LSD1 (unknown origin) assessed as inhibition constant by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346865(CHEMBL1797642 | 2-PFPA)
Affinity DataKi:  8.30E+3nMAssay Description:Inhibition of human recombinant MAO-B using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataKi:  1.60E+4nMAssay Description:Irreversible inhibition of MAO-B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human recombinant MAO-B using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346865(CHEMBL1797642 | 2-PFPA)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of hexahistidine-tagged LSD1 (unknown origin) (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346589(CHEMBL255520 | CHEMBL1795974)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of human recombinant LSD1/CoREST expressed in Escherichia coli using Lys4 monomethylated histone H3 peptide as substrate assessed as inhib...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of human recombinant MAO-B using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346865(CHEMBL1797642 | 2-PFPA)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of human recombinant MAO-A using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50616050(CHEMBL5439284)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of human recombinant LSD1/CoREST expressed in Escherichia coli using Lys4 monomethylated histone H3 peptide as substrate assessed as inhib...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50568521(CHEMBL4878787)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of MAO-B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1B(Mouse)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346864(CHEMBL1797641 | CHEMBL3104337 | US8765820, 8)
Affinity DataKi:  3.80E+4nMAssay Description:Inhibition of mouse recombinant LSD2 expressed in Escherichia coli using Lys4 dimethylated histone H3 peptide assessed as inhibition constant by pero...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346866(CHEMBL1797643 | S1201)
Affinity DataKi:  4.20E+4nMAssay Description:Inhibition of human recombinant MAO-B using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1B(Mouse)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346863(CHEMBL1797640 | US8765820, 5b)
Affinity DataKi:  6.10E+4nMAssay Description:Inhibition of mouse recombinant LSD2 expressed in Escherichia coli using Lys4 dimethylated histone H3 peptide assessed as inhibition constant by pero...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific histone demethylase 1B(Mouse)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346589(CHEMBL255520 | CHEMBL1795974)
Affinity DataKi:  6.10E+4nMAssay Description:Inhibition of mouse recombinant LSD2 expressed in Escherichia coli using Lys4 dimethylated histone H3 peptide assessed as inhibition constant by pero...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346866(CHEMBL1797643 | S1201)
Affinity DataKi:  6.40E+4nMAssay Description:Inhibition of human recombinant MAO-A using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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