Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50019514
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50608076(CHEMBL5281547)
Affinity DataKd:  1.04E+4nMAssay Description:Inhibition of NSD1 (unknown origin) by ITC assay assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GLP (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of G9a (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human PRMT6 using S-adenosyl-L-methionine (3H) as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PRMT8 using S-adenosyl-L-methionine (3H) as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50501525(CHEMBL4086403)
Affinity DataIC50: 7nMAssay Description:Inhibition of GLP (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: 15nMAssay Description:Inhibition of G9a (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: 19nMAssay Description:Inhibition of GLP (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human PRMT1 using S-adenosyl-L-methionine (3H) as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50620073(CHEMBL5429668)
Affinity DataIC50: 47nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50590381(CHEMBL5173402)
Affinity DataIC50: 64nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 83nMAssay Description:Inhibition of human PRMT4 using S-adenosyl-L-methionine (3H) as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 119nMAssay Description:Inhibition of human PRMT3 using S-adenosyl-L-methionine (3H) as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 210nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50075100(CHEMBL3414625)
Affinity DataIC50: 500nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataIC50: 700nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of NSD1 (unknown origin) measured after 16 hrs by MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50346713(CHEMBL1797447)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of G9a (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50620074(CHEMBL5412253)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant human PRMT1 expressed in Escherichia coli DE3 cells using AcH4-21 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of NSD1 (unknown origin) measured after 4 hrs by MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50620076(CHEMBL5432754)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant Full-length human PRMT1 by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50620075(CHEMBL5411843)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of recombinant Full-length human PRMT1 by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of GLP (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50608076(CHEMBL5281547)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of NSD1 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed