Compile Data Set for Download or QSAR
Report error Found 162 Enz. Inhib. hit(s) with all data for entry = 50019955
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163508(US9687479, 22 N-[(5-chlorothiophen-2-yl)methyl]-1-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163513(US9687479, 301 1-(5-[(4-fluorophenyl)methyl]amino-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625010(CHEMBL5428035)
Affinity DataIC50: 1nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM162366(US9687479, 3 3-(5-[(5-chlorothiophen-2-yl)methyl]a...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625013(CHEMBL5410746)
Affinity DataIC50: 1nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625004(CHEMBL5427798)
Affinity DataIC50: 2nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163396(US9687479, 272 1-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163676(US9687479, 368 N-[(4-fluorophenyl)methyl]-1-[(2-me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM164103(US9687479, 383 N-[(5-chlorofuran-2-yl)methyl]-1-[(...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163539(US9687479, 319 1-(5-[(4-methoxyphenyl)methyl]amino...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163420(US9687479, 287 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163675(US9687479, 367 N-[(4-fluorophenyl)methyl]-1-[(2-me...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625008(CHEMBL5399103)
Affinity DataIC50: 4nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163397(US9687479, 273 1-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163457(US9687479, 14 3-(5-[(4-fluorophenyl)methyl]sulfany...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM164180(US9687479, 397 N-benzyl-1-[(2-methoxyphenyl)carbon...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM164178(US9687479, 395 N-benzyl-1-[(2-chlorophenyl)carbony...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163407(US9687479, 278 1-[(2-methoxyphenyl)carbonyl]-3-(py...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163386(US9687479, 266 1-(5-[(4-fluorophenyl)methyl]amino-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625009(CHEMBL5402462)
Affinity DataIC50: 5nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625006(CHEMBL5424533)
Affinity DataIC50: 6nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetCoagulation factor X(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM7840(RIVAROXABAN | US8822458, 97 | US8822458, 44)
Affinity DataIC50: 6nMAssay Description:Inhibition of human factor Xa using S-2765 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 min...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM33832([5-(benzylamino)-3-pyridin-3-yl-1,2,4-triazol-1-yl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50624983(CHEMBL5427665)
Affinity DataIC50: 7nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50624991(CHEMBL5418843)
Affinity DataIC50: 7nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163515(US9687479, 302 1-(5-[(4-fluorophenyl)methyl]amino-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50624996(CHEMBL5426702)
Affinity DataIC50: 8nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163391(US9687479, 271 1-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625025(CHEMBL5428764)
Affinity DataIC50: 8nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM33812(1-[5-[(4-fluorophenyl)methylamino]-3-(3-pyridinyl)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50624995(CHEMBL5396825)
Affinity DataIC50: 9nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163421(US9687479, 288 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163592(US9687479, 358 1-benzoyl-N-[(4-fluorophenyl)methyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625007(CHEMBL5400494)
Affinity DataIC50: 10nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163385(US9687479, 24 1-(5-[(5-chlorothiophen-2-yl)methyl]...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163556(US9687479, 334 1-[(2-methoxyphenyl)carbonyl]-3-phe...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625005(CHEMBL5409452)
Affinity DataIC50: 12nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625019(CHEMBL5406565)
Affinity DataIC50: 12nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625015(CHEMBL5437092)
Affinity DataIC50: 19nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50624997(CHEMBL5410338)
Affinity DataIC50: 20nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50624977(CHEMBL5420677)
Affinity DataIC50: 23nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163387(US9687479, 267 1-(5-[(4-fluorophenyl)methyl]amino-...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625001(CHEMBL5411345)
Affinity DataIC50: 25nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625029(CHEMBL5420780)
Affinity DataIC50: 25nMAssay Description:Inhibition of human alpha-thrombin using Boc-Val-Pro-Arg-AMC as substrate measured every 1 min for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163522(US9687479, 307 1-(5-[(4-fluorophenyl)methyl]amino-...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163577(US9687479, 348 1-[5-(benzylamino)-3-(pyridin-2-yl)...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM50625018(CHEMBL5395380)
Affinity DataIC50: 30nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163399(US9687479, 274 1-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Bovine)
Verseon

Curated by ChEMBL
LigandPNGBDBM50280655(3-Isobutyryloxy-benzo[4,5]thieno[3,2-b]furan-2-car...)
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine thrombin using Bz-Phe-Val-Arg-pNA as substrate by absorbance based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163419(US9687479, 286 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
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