Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50018555
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells clamped at -80 mV stimulated +20 mV for 2 sec followed by repolarized to -50 mV for 5 secs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells clamped at -80 mV stimulated +20 mV for 2 sec followed by repolarized to -50 mV for 5 secs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome suspension using diclofenac substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsome suspension using diclofenac substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsome suspension using dextromethorphan substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsome suspension using amodiaquine substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsome suspension using dextromethorphan substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsome suspension using midazolam substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsome suspension using amodiaquine substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsome suspension using omeprazole substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsome suspension using midazolam substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsome suspension using omeprazole substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 1.61E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsome suspension using phenacetin substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsome suspension using phenacetin substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed