Compile Data Set for Download or QSAR
Report error Found 86 Enz. Inhib. hit(s) with all data for entry = 50018147
TargetATP-dependent translocase ABCB1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405520(CHEMBL1822601)
Affinity DataEC50:  7.30E+3nMAssay Description:Inhibition of P-gp transporter (unknown origin) expressed in dog MDCK-MDR1 assessed as inhibition of fluorescent Calcein-AM transport by fluorescence...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405519(CHEMBL5278314)
Affinity DataEC50:  800nMAssay Description:Inhibition of P-gp transporter (unknown origin) expressed in dog MDCK-MDR1 assessed as inhibition of fluorescent Calcein-AM transport by fluorescence...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405515(CHEMBL4792070)
Affinity DataIC50: 45nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 860nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic 3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic 4 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic 2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50559171(Blarcamesine | Anavex 2-73 | Anavex)
Affinity DataIC50: 3.30E+3nMAssay Description:Binding affinity to muscarinic 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50398057(CHEMBL2181924)
Affinity DataKi:  0.00250nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50251208(CHEMBL4088272)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to human sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405519(CHEMBL5278314)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [H3]DTG from sigma 1 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405520(CHEMBL1822601)
Affinity DataKi:  0.630nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405518(CHEMBL5291247)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to sigma 1 receptor expressed in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405523(CHEMBL5278355)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL521582 | [2-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50569768(CHEMBL4860790)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50038419(N-(1-Benzyl-piperidin-4-yl)-4-iodo-benzamide | CHE...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405517(CHEMBL5279451)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to sigma 1 receptor expressed in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50216057(N-[6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl-b...)
Affinity DataKi:  2nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405515(CHEMBL4792070)
Affinity DataKi:  2nMAssay Description:Displacement of [H3]DTG from sigma 1 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405522(CHEMBL5274755)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to human sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405512(CHEMBL5270434)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to human sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50445477(CHEMBL3104856)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to sigma 1 receptor expressed in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405513(CHEMBL5274616)
Affinity DataKi:  3.70nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405514(CHEMBL5273358)
Affinity DataKi:  4nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50338990(CHEMBL2311153 | N-phenylpropyl-N''-3,4-dimethoxyph...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50569767(CHEMBL4858036)
Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405530(CHEMBL5283424)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant incubated for 150 mins ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405516(ROLUPERIDONE | Roluperidone | FMI | MIN-101 FREE B...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) by Tango assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405518(CHEMBL5291247)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin) expressed in human RPMI-8226 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50210268(CHEMBL3984952)
Affinity DataKi:  7.70nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50445476(CHEMBL3104857)
Affinity DataKi:  7.80nMAssay Description:Binding affinity to sigma 1 receptor expressed in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405528(CHEMBL5291479)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405519(CHEMBL5278314)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant in presence of (+)-pentazocine by radi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405516(ROLUPERIDONE | Roluperidone | FMI | MIN-101 FREE B...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataKi:  11nMAssay Description:Displacement of [H3]DTG from sigma 1 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50092741(N-(2-Diethylamino-ethyl)-3-iodo-4-methoxy-benzamid...)
Affinity DataKi:  12nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataKi:  13nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405520(CHEMBL1822601)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant in presence of (+)-pentazocine by radi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405518(CHEMBL5291247)
Affinity DataKi:  14nMAssay Description:Binding affinity to sigma 2 receptor expressed in rat liverMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405517(CHEMBL5279451)
Affinity DataKi:  16nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin) expressed in human RT-4 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405511(T-817 | Edonerpic | J2.972.359A)
Affinity DataKi:  16nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405525(CHEMBL5267888)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50396352(CHEMBL2170062)
Affinity DataKi:  17nMAssay Description:Binding affinity to human sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50308028(4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine | ...)
Affinity DataKi:  17nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma intracellular receptor 2(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  18nMAssay Description:Binding affinity to human sigma 2 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405526(CHEMBL5277371)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
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