Compile Data Set for Download or QSAR
Report error Found 73 Enz. Inhib. hit(s) with all data for entry = 50018146
TargetProcathepsin L(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of Cathepsin L (unknown origin) preincubated for 30 mins followed by fluorogenic substrate addition and measured for 15 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM442762(MPI6)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Cathepsin L using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 30 mins followed by substrate addition by fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405463(CHEMBL5267069)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM423466(WO2006061714-ID-11 | WO2006061714, P39.1 | cmdc.20...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of N-terminal His-SUMO tagged SARS-CoV-2 Main protease transfected in Escherichia coli BL21 (DE3) using DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405469(CHEMBL5267414)
Affinity DataIC50: 14nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50598148(CHEMBL5193976)
Affinity DataIC50: 15nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405459(CHEMBL5290282)
Affinity DataIC50: 15nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405458(CHEMBL5290927)
Affinity DataIC50: 16nMAssay Description:Inhibition of SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using MCA-AVLQSGFR-Lys(DNP)-Lys-NH2 as fluorogenic peptide measured fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405464(CHEMBL5270743)
Affinity DataIC50: 17nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataIC50: 19nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50598146(CHEMBL5195364)
Affinity DataIC50: 28nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM61971(KSC-6-175 | cid_22416237 | 5-bromanyl-2-phenyl-1,2...)
Affinity DataIC50: 30nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM512835(acs.jmedchem.1c00409_ST.430)
Affinity DataIC50: 34nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM420297(med.21724, Compound 62 | peptidomimetic aldehydes ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli using MCA-AVLQSGFR-Lys(DNP)-Lys-NH2 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405456(CHEMBL5287345)
Affinity DataIC50: 45nMAssay Description:Inhibition of C-terminal His-tagged SARS-CoV-2 BetaCoV/Wuhan/WIV04/2019 Main protease expressed in Escherichia coli using Dabcyl-KTSAVLQ/SGFRKME(Edan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405455(CHEMBL3427167)
Affinity DataIC50: 45nMAssay Description:Inhibition of C-terminal His-tagged SARS-CoV-2 BetaCoV/Wuhan/WIV04/2019 Main protease expressed in Escherichia coli using Dabcyl-KTSAVLQ/SGFRKME(Edan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 51nMAssay Description:Inhibition of SARS-CoV-2 Main protease expressed in Escherichia coli preincubated for 30 mins followed by substrate addition and measured for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli using MCA-AVLQSGFR-Lys(DNP)-Lys-NH2 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataIC50: 54nMAssay Description:Inhibition of SARS-CoV-2 Main protease expressed in Escherichia coli preincubated for 30 mins followed by substrate addition and measured for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM429426(med.21724, Compound 99 | acs.jmedchem.1c00409_ST.4...)
Affinity DataIC50: 55nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405467(CHEMBL5278950)
Affinity DataIC50: 56nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM512571(acs.jmedchem.1c00409_ST.164)
Affinity DataIC50: 74nMAssay Description:Inhibition of SARS-CoV-2 Main protease expressed in Escherichia coli BL21-Gold (DE3) using Mca-AVLQSGFR-K(Dnp)K as substrate incubated for 30 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405466(CHEMBL5281998)
Affinity DataIC50: 80nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM429299(jm5b01461, Compound 119 | MAC-5576)
Affinity DataIC50: 81nMAssay Description:Inhibition of N-terminal GST-tagged SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using MCA-AVLQSGFR-Lys(DNP)-Lys-NH2 as fluorogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM442762(MPI6)
Affinity DataIC50: 105nMAssay Description:Inhibition of N-terminal His-SUMO tagged SARS-CoV-2 Main protease transfected in Escherichia coli BL21 (DE3) using DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM512583(acs.jmedchem.1c00409_ST.176)
Affinity DataIC50: 110nMAssay Description:Inhibition of SARS-CoV-2 Main protease expressed in Escherichia coli BL21-Gold (DE3) using Mca-AVLQSGFR-K(Dnp)K as substrate incubated for 30 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 130nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405472(CHEMBL5267356)
Affinity DataIC50: 151nMAssay Description:Inhibition of N-terminal GST-tagged SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using MCA-AVLQSGFR-Lys(DNP)-Lys-NH2 as fluorogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405477(CHEMBL5270421)
Affinity DataIC50: 160nMAssay Description:Inhibition of SARS-CoV-2 3CL protease incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 180nMAssay Description:Inhibition of SARS-CoV-2 Main protease transfected in Escherichia coli BL21-Gold (DE3) using (Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 as substrate by FRET ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM419133(GC376 | BDBM429386)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) using Abz-SVTLQSG-Y(NO2)-R as substrate incubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50435400(CHEMBL99313 | acs.jmedchem.1c00409_ST.173)
Affinity DataIC50: 190nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 200nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405476(CHEMBL5287202)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal GST-tagged recombinant full length SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using MCA-AVLQSGFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405475(CHEMBL5288812)
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal GST-tagged recombinant full length SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using MCA-AVLQSGFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405510(CHEMBL5274000)
Affinity DataIC50: 320nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405504(CHEMBL3916514)
Affinity DataIC50: 320nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405500(CHEMBL5290840)
Affinity DataIC50: 345nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) cells using Mca-AVLQSGFR-K(Dnp)K as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405499(CHEMBL5280925)
Affinity DataIC50: 363nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) cells using Mca-AVLQSGFR-K(Dnp)K as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405454(CHEMBL4850298)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) using Abz-SVTLQSG-Y(NO2)-R as substrate incubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405509(CHEMBL416639)
Affinity DataIC50: 410nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405465(CHEMBL5283004)
Affinity DataIC50: 430nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405471(CHEMBL5266148)
Affinity DataIC50: 450nMAssay Description:Inhibition of SARS-CoV-2 BetaCoV/Wuhan/WIV04/2019 Main protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQ/SGFRKME(Edans) as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405502(CHEMBL5279145)
Affinity DataIC50: 467nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) cells using Mca-AVLQSGFR-K(Dnp)K as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 490nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405468(CHEMBL5287918)
Affinity DataIC50: 530nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) cells using Mca-AVLQSGFR-K(Dnp)K as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 670nMAssay Description:Inhibition of SARS-CoV-2 Main protease transfected in Escherichia coli BL21-Gold (DE3) using (Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 as substrate by FRET ...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405503(CHEMBL5273811)
Affinity DataIC50: 824nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) cells using Mca-AVLQSGFR-K(Dnp)K as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM50405470(CHEMBL5287068)
Affinity DataIC50: 830nMAssay Description:Inhibition of SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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