Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50019928
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624747(CHEMBL5424300)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human topoisomerase 2-alpha assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis met...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624746(CHEMBL5399261)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human topoisomerase 2-alpha assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis met...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624747(CHEMBL5424300)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of human topoisomerase 2-alpha using pBR322 DNA as substrate incubated for 30 mins in presence of 0.5 to 5 mM ATP (Rvb = 2.9 microM)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624746(CHEMBL5399261)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624746(CHEMBL5399261)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human topoisomerase 2-alpha using pBR322 DNA as substrate incubated for 30 mins in presence of 0.5 to 5 mM ATP (Rvb = 3.4 microM)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624749(CHEMBL5418790)
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibition of human topoisomerase 2-alpha assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis met...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624747(CHEMBL5424300)
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 3.61E+4nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624748(CHEMBL5430260)
Affinity DataIC50: 5.98E+4nMAssay Description:Inhibition of human topoisomerase 2-alpha assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis met...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of human topoisomerase 2-alpha assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624749(CHEMBL5418790)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed