Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50016969
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human plasma coagulation factor XIa using Boc-Glu(OBzl)-Ala-Arg-MCA as substrate preincubated for 5 to 15 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlasma kallikrein(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataIC50: 23nMAssay Description:Inhibition of C-terminal 6-His tagged human plasma kallikrein (20 to 638 residues) using Z-FR-AMC as substrate preincubated for 5 to 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetProthrombin(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human thrombin using H-D-CHA -Ala-Arg-AMC.2AcOH as substrate preincubated for 5 to 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human plasma coagulation factor Xa using CH3SO2-D-CHA-Gly-Arg-AMC-AcOH as substrate preincubated for 5 to 15 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598740(CHEMBL5175227)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598739(CHEMBL5188215)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598738(CHEMBL5204065)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598737(CHEMBL5205631)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598741(CHEMBL5204894)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598725(CHEMBL5185397)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598743(CHEMBL5178223)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598745(CHEMBL5198823)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598734(CHEMBL5197480)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598736(CHEMBL5208095)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598744(CHEMBL5190323)
Affinity DataKi:  0.420nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598732(CHEMBL5192284)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598742(CHEMBL5182855)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598729(CHEMBL5195600)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598727(CHEMBL5198338)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598735(CHEMBL5193267)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598730(CHEMBL5204289)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598731(CHEMBL5198972)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598733(CHEMBL5188316)
Affinity DataKi:  6.40nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598726(CHEMBL5171252)
Affinity DataKi:  7.80nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598728(CHEMBL5180591)
Affinity DataKi:  61nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed