Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50016151
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592848(CHEMBL5186232)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM271626(US10065941, Compound I-127 | US9732060, Compound I...)
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM319844(US10174016, Example 11 | 3-(5-Methyl-1,3-thiazol-2...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592849(CHEMBL5207245)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50533006(Af-219 | Gefapixant | R-1646 | R1646 | RG-1646 | R...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592842(CHEMBL5170554)
Affinity DataIC50: 1.93E+3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592832(CHEMBL5178333)
Affinity DataIC50: 3.07E+3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592833(CHEMBL5178054)
Affinity DataIC50: 3.43E+3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592834(CHEMBL5186736)
Affinity DataIC50: 5.61E+3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592843(CHEMBL5182519)
Affinity DataIC50: 8.56E+3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592835(CHEMBL5199426)
Affinity DataIC50: 8.72E+3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592836(CHEMBL5201961)
Affinity DataIC50: 9.76E+3nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592837(CHEMBL5175267)
Affinity DataIC50: 1.04E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592844(CHEMBL5191901)
Affinity DataIC50: 1.09E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592838(CHEMBL5194075)
Affinity DataIC50: 1.15E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592845(CHEMBL5182831)
Affinity DataIC50: 1.34E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592839(CHEMBL5194597)
Affinity DataIC50: 1.38E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592846(CHEMBL5196092)
Affinity DataIC50: 1.55E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592840(CHEMBL5193198)
Affinity DataIC50: 1.84E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592847(CHEMBL5192824)
Affinity DataIC50: 1.90E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50592841(CHEMBL5185378)
Affinity DataIC50: 2.19E+4nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMed