Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with all data for entry = 50016959
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598654(CHEMBL5169996)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50088376(CHEBI:49005 | Deferasirox | Exjade | ICL670A | US1...)
Affinity DataEC50:  4.05E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598655(CHEMBL5178246)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of KDM4C in human KYSE-150 cells overexpressing KDM4C assessed as increase in H3K36me3 measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598662(CHEMBL5181544)
Affinity DataEC50:  1.05E+5nMAssay Description:Inhibition of binding of H3K4Me3 to KDM4A tudor domain (unknown origin) measured by NanoBRET-based cellular proximity assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598661(CHEMBL5203487)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of KDM4C (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598661(CHEMBL5203487)
Affinity DataIC50: 6nMAssay Description:Inhibition of KDM4A (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158844(CHEMBL3785491)
Affinity DataIC50: 10nMAssay Description:Inhibition of human KDM4B (1 to 500 residues) measured by antibody-based fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4D(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598656(CHEMBL5206330)
Affinity DataIC50: 23nMAssay Description:Inhibition of KDM4D (unknown origin) measured by AlphaLisa-based screening assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50151923(CHEMBL3774537)
Affinity DataIC50: 23nMAssay Description:Inhibition of human KDM5B using H3(1-21)K4-Me3-GGK Biotin as substrate and measured by Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5D(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5D (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5A (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5B (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5C (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50151923(CHEMBL3774537)
Affinity DataIC50: 31nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KDM4B (1 to 500 residues) expressed in baculovirus-infected Sf9 cells using ARTKQTARK(Me3)STGGK...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598660(CHEMBL5203308)
Affinity DataIC50: 33nMAssay Description:Inhibition of KDM4A (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598660(CHEMBL5203308)
Affinity DataIC50: 33nMAssay Description:Inhibition of KDM4C (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598660(CHEMBL5203308)
Affinity DataIC50: 33nMAssay Description:Inhibition of KDM4B (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4D(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 35nMAssay Description:Inhibition of KDM4D (unknown origin) using H3K9me3 as substrate and measured by LANCE TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 35nMAssay Description:Inhibition of KDM4C (unknown origin) using H3K9me3 as substrate and measured by LANCE TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 35nMAssay Description:Inhibition of KDM4B (unknown origin) using H3K9me3 as substrate and measured by LANCE TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 35nMAssay Description:Inhibition of KDM4A (unknown origin) using H3K9me3 as substrate and measured by LANCE TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50151392(CHEMBL3775262)
Affinity DataIC50: 64nMAssay Description:Inhibition of KDM4C (1 to 352 residues) (unknown origin) using biotin-tagged histone H3 (residues 1-21) lysine 9 trimethylated peptide as substrate i...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4D(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50153318(CHEMBL3775237)
Affinity DataIC50: 79nMAssay Description:Inhibition of KDM4D (unknown origin) measured by RapidFire mass spectrometry (RFMS)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50153318(CHEMBL3775237)
Affinity DataIC50: 79nMAssay Description:Inhibition of KDM4C (unknown origin) measured by RapidFire mass spectrometry (RFMS)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50153318(CHEMBL3775237)
Affinity DataIC50: 79nMAssay Description:Inhibition of KDM5C (unknown origin) measured by RapidFire mass spectrometry (RFMS)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50008057(CHEBI:64153 | BMS-722782 | TANESPIMYCIN)
Affinity DataIC50: 130nMAssay Description:Inhibition of KDM5A (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50008059(CHEBI:5292 | GELDANAMYCIN)
Affinity DataIC50: 130nMAssay Description:Inhibition of KDM5A (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50005781(CHEBI:65324 | ALVESPIMYCIN)
Affinity DataIC50: 130nMAssay Description:Inhibition of KDM5A (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4E(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50: 200nMAssay Description:Inhibition of human KDM4E heterogenously expressed in Escherichia coli using biotin-H3(1-15)K9Me3 as substrate and measured by Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 230nMAssay Description:Inhibition of KDM5A (unknown origin) measured by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataIC50: 280nMAssay Description:Inhibition of KDM2A in human MIA PaCa-2 cells assessed as induction of H3K36me2 measured by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598657(GNF-Pf-1339 | CHEMBL600353)
Affinity DataIC50: 280nMAssay Description:Inhibition of KDM2A in human MIA PaCa-2 cells assessed as induction of H3K36me2 measured by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 2A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataIC50: 280nMAssay Description:Inhibition of KDM2A in human MIA PaCa-2 cells assessed as induction of H3K36me2 measured by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataIC50: 280nMAssay Description:Inhibition of KDM4A in human MIA PaCa-2 cells assessed as induction of H3K9me3 measured by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598657(GNF-Pf-1339 | CHEMBL600353)
Affinity DataIC50: 280nMAssay Description:Inhibition of KDM4A in human MIA PaCa-2 cells assessed as induction of H3K9me3 measured by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataIC50: 280nMAssay Description:Inhibition of KDM4A in human MIA PaCa-2 cells assessed as induction of H3K9me3 measured by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4E(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 290nMAssay Description:Inhibition of N-terminal His6-tagged human KDM4E (1 to 337 residues) measured by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 290nMAssay Description:Inhibition of human KDM4A (1 to 350 residues) measured by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 290nMAssay Description:Inhibition of KDM4B (unknown origin) measured by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 290nMAssay Description:Inhibition of KDM4C (unknown origin) measured by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4D(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataIC50: 290nMAssay Description:Inhibition of His-tagged human KDM4D (1 to 350 residues) measured by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 6B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50008059(CHEBI:5292 | GELDANAMYCIN)
Affinity DataIC50: 400nMAssay Description:Inhibition of KDM6B (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 6B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50005781(CHEBI:65324 | ALVESPIMYCIN)
Affinity DataIC50: 400nMAssay Description:Inhibition of KDM6B (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 6B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50008057(CHEBI:64153 | BMS-722782 | TANESPIMYCIN)
Affinity DataIC50: 400nMAssay Description:Inhibition of KDM6B (unknown origin) measured by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4D(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50242878(CHEMBL4090908)
Affinity DataIC50: 410nMAssay Description:Inhibition of KDM4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5A (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5B (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5C (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5D(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5D (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
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