Compile Data Set for Download or QSAR
Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 50016818
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597493(CHEMBL5192610)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597488(CHEMBL5180112)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597490(CHEMBL5199904)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597489(CHEMBL5208605)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597473(CHEMBL5181094)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597492(CHEMBL5186165)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597494(CHEMBL5188032)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597485(CHEMBL5183751)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597487(CHEMBL5169406)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597475(CHEMBL5200987)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50097166(CHEMBL3580669)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50097165(CHEMBL3581146)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597495(CHEMBL5174891)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50: 25nMAssay Description:Inhibition of wild-type human full length LIMK2 (M1 to P638 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597471(CHEMBL5176687)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597491(CHEMBL5201650)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597478(CHEMBL5209364)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597473(CHEMBL5181094)
Affinity DataIC50: 39nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597486(CHEMBL5187325)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597481(CHEMBL5193152)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597470(CHEMBL5207169)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597474(CHEMBL5171140)
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597479(CHEMBL5184099)
Affinity DataIC50: 98nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 143nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597472(CHEMBL5186844)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597471(CHEMBL5176687)
Affinity DataIC50: 320nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597484(CHEMBL5197969)
Affinity DataIC50: 534nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50: 790nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597482(CHEMBL5187811)
Affinity DataIC50: 851nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50: 1.10E+3nMAssay Description:Time dependent inhibition of CYP1A2 in pooled human liver microsomes using midazolam as substrate preincubated for 30 mins in presence of NADPH follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597489(CHEMBL5208605)
Affinity DataIC50: 1.10E+3nMAssay Description:Time dependent inhibition of CYP1A2 in pooled human liver microsomes using midazolam as substrate preincubated for 30 mins in presence of NADPH follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597476(CHEMBL5205297)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597477(CHEMBL5171976)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597489(CHEMBL5208605)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597471(CHEMBL5176687)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597485(CHEMBL5183751)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597490(CHEMBL5199904)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597472(CHEMBL5186844)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597480(CHEMBL5207486)
Affinity DataIC50: 4.33E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597483(CHEMBL5209466)
Affinity DataIC50: 4.79E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597479(CHEMBL5184099)
Affinity DataIC50: 5.03E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597493(CHEMBL5192610)
Affinity DataIC50: 6.65E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597492(CHEMBL5186165)
Affinity DataIC50: 8.14E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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