Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50018114
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataKd: 11nMAssay Description:Binding affinity to human VHL by isothermal calorimetric assayMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Displacement of dBET6 from CRBN (unknown origin) transfected in BRD4 BD2-GFP mCherry report cells incubated for 5 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 703nMAssay Description:Displacement of dBET6 from CRBN (unknown origin) transfected in BRD4 BD2-GFP mCherry report cells incubated for 5 hrsMore data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Human)
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 218nMAssay Description:Inhibition of His-tagged TRIM24 (unknown origin) expressed in Escherichia coli BL21(DE3)pLysS competent cells using biotinylated-H3K23ac peptide as s...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Binding affinity to RNF114 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 247nMAssay Description:Inhibition of HCV NS3/4a protease in Huh7.5 SGR cells using [Ac-DE-D(Edans)-EE-Abu-[COO]AS-K(Dabcyl)-NH2] as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Human)
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 338nMAssay Description:Inhibition of His-tagged TRIM24 (unknown origin) expressed in Escherichia coli BL21(DE3)pLysS competent cells using biotinylated-H3K23ac peptide as s...More data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Binding affinity to RNF4 (unknown origin)More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Binding affinity to VHL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Binding affinity to FEM1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Binding affinity to RNF4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Displacement of p53 from human MDM2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Displacement of p53 from human MDM2 by HTRF assayMore data for this Ligand-Target Pair
3D Structure (crystal)