Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50016072
TargetCytochrome P450 2D6(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591916(CHEMBL5177903)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2D6 in human kidney microsomes assessed as inhibition of 20-HETE formation using 3-[2-(N,N-diethyl-N-methyl-amino)ethyl]-7-methoxy-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2D6 in human kidney microsomes assessed as inhibition of 20-HETE formation using 3-[2-(N,N-diethyl-N-methyl-amino)ethyl]-7-methoxy-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591916(CHEMBL5177903)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2C9 in human kidney microsomes assessed as inhibition of 20-HETE formation using 7-methoxy-4-trifluoromethylcoumarin as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP3A4 in human kidney microsomes assessed as inhibition of 20-HETE formation using 7-benzyl-oxyquinoline as substrate in presence of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591916(CHEMBL5177903)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP3A4 in human kidney microsomes assessed as inhibition of 20-HETE formation using 7-benzyl-oxyquinoline as substrate in presence of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50106737(N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2C9 in human kidney microsomes assessed as inhibition of 20-HETE formation using 7-methoxy-4-trifluoromethylcoumarin as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591918(7-Methoxyflavone | 7-METHOXYFLAVONE)
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant CYP19A1 (unknown origin) using dibenzylfluorescein as substrate incubated for 30 mins in presence of NADPH by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4F2(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human CYP4F2 expressed in baculovirus-infected insect cells in presence of arachidonic acid and NADPH incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4F2(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 870nMAssay Description:Inhibition of recombinant human CYP4F2 expressed in baculovirus-infected insect cells in presence of arachidonic acid and NADPH incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAromatase(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM26664(7-Hydroxy-flavone, 5a | 7-Hydroxyflavone, 11 | 7-h...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant CYP19A1 (unknown origin) using dibenzylfluorescein as substrate incubated for 30 mins in presence of NADPH by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4F2(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591917(CHEBI:69527 | Rubiarbonone C | RUBIARBONONE C)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of recombinant CYP4F2 (unknown origin) incubated for 5 to 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2J2(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human CYP2J2 expressed in baculovirus-infected insect cells in presence of arachidonic acid and NADPH incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 4A11(Human)
University of Wuppertal

Curated by ChEMBL
LigandPNGBDBM50591915(CHEMBL2130955)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human CYP4A11 expressed in baculovirus-infected insect cells in presence of arachidonic acid and NADPH incubated for 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed