Compile Data Set for Download or QSAR
Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 50017855
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  220nMAssay Description:Binding affinity to wild-type human partial length LRRK2 (H970 to E2527 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  46nMAssay Description:Binding affinity to wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase A(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  290nMAssay Description:Binding affinity to wild-type human partial length AURKA (E122 to K401 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  380nMAssay Description:Binding affinity to wild-type human partial length FGFR1 (P357 to V669 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase DCLK1(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  61nMAssay Description:Binding affinity to wild-type human partial length DCLK1 (L270 to A662 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  420nMAssay Description:Binding affinity to human partial length KIT (I571 to D952 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to human partial length ABL1 by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to wild type human partial length MEK5 (L98 to P448 residues) expressed in mammalian expression system by Kinomescan binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  180nMAssay Description:Binding affinity to wild-type human partial length MAPK7 (M1 to A409 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild type human partial length JAK3 (I781 to S1124 residues) expressed in mammalian expression system by Kinomescan binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human BRD4 BD1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605525(CHEMBL5175191)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605526(CHEMBL5188920)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605527(CHEMBL5186248)
Affinity DataIC50: 6nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605523(CHEMBL5197199)
Affinity DataIC50: 7nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605535(CHEMBL5198962)
Affinity DataIC50: 7nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605522(CHEMBL5172952)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK5 (unknown origin) incubated for 1 hr by KiNativ profiling analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605520(CHEMBL5202924)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605519(CHEMBL5175007)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605521(CHEMBL5173346)
Affinity DataIC50: 14nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605528(CHEMBL5175760)
Affinity DataIC50: 14nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605536(CHEMBL5208879)
Affinity DataIC50: 16nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605533(CHEMBL5180089)
Affinity DataIC50: 19nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605523(CHEMBL5197199)
Affinity DataIC50: 20nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605534(CHEMBL5208123)
Affinity DataIC50: 22nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605524(CHEMBL5193573)
Affinity DataIC50: 25nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605527(CHEMBL5186248)
Affinity DataIC50: 31nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50507989(CHEMBL4445670)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged ERK5 (1 to 398 residues) expressed in Escherichia coli using biotinylated peptide Ahx-PPGDYSTTP...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605518(CHEMBL5179461)
Affinity DataIC50: 37nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605521(CHEMBL5173346)
Affinity DataIC50: 43nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605528(CHEMBL5175760)
Affinity DataIC50: 58nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 59nMAssay Description:Inhibition of ERK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605522(CHEMBL5172952)
Affinity DataIC50: 60nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605526(CHEMBL5188920)
Affinity DataIC50: 70nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605517(CHEMBL5209433)
Affinity DataIC50: 72nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50: 77nMAssay Description:Inhibition of ERK5 (1 to 492 residues) in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by du...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50: 79nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605529(CHEMBL5171050)
Affinity DataIC50: 99nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50: 141nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605512(CHEMBL5175353)
Affinity DataIC50: 400nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605532(CHEMBL5194814)
Affinity DataIC50: 642nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605535(CHEMBL5198962)
Affinity DataIC50: 671nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50516388(CHEMBL4453232)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant N-terminal His-tagged / TEV cleavage site fused ERK5 (2 to 409 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605533(CHEMBL5180089)
Affinity DataIC50: 787nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605514(CHEMBL5176592)
Affinity DataIC50: 790nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50: 820nMAssay Description:Inhibition of human recombinant N-terminal His-tagged / TEV cleavage site fused ERK5 (2 to 409 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length ERK5 in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by dual lucif...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605530(CHEMBL5179069)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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