Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50017741
TargetCytochrome c oxidase subunit 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant COX-2 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 280nMAssay Description:Inhibition of COX-1 in human whole blood assessed as reduction in thromboxane B2 production by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 300nMAssay Description:Inhibition of COX-2 in LPS-stimulated human whole blood assessed as reduction in PGE2 production by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant COX-1 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of human recombinant COX-1 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed