Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50016447
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595028(CHEMBL5174883)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at human TLR4 expressed in HEK-blue hTLR4/MD2-CE14 cells cotransfected with pISRE-TA plasmid assessed as reduction in ISRE activa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595028(CHEMBL5174883)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human TLR4 expressed in HEK-blue hTLR4/MD2-CE14 cells cotransfected with pNiFty plasmid assessed as reduction in NF-kappaB act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595024(CHEMBL5193233)
Affinity DataIC50: 150nMAssay Description:Binding affinity to TLR4 in human THP-1 monocytes after 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595023(CHEMBL5183013)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of LPS-stimulated TLR4 activation in HEK-Blue-hTLR4 cells assessed as reduction in SEAP release preincubated for 15 mins followed by LPS s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595021(CHEMBL5193111)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of LPS-stimulated TLR4 activation in HEK-Blue-hTLR4 cells assessed as reduction in SEAP release preincubated for 15 mins followed by LPS s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595020(CHEMBL5198865)
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of LPS-stimulated TLR4 activation in HEK-Blue-hTLR4 cells assessed as reduction in SEAP release preincubated for 15 mins followed by LPS s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595019(CHEMBL5191555)
Affinity DataIC50: 5.91E+3nMAssay Description:Inhibition of LPS-stimulated TLR4 activation in HEK-Blue-hTLR4 cells assessed as reduction in SEAP release preincubated for 15 mins followed by LPS s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595022(CHEMBL5184274)
Affinity DataIC50: 6.61E+3nMAssay Description:Inhibition of LPS-stimulated TLR4 activation in HEK-Blue-hTLR4 cells assessed as reduction in SEAP release preincubated for 15 mins followed by LPS s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595025(CHEMBL5175448)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human TLR4 expressed in HEK293-Blue hTLR4 cells assessed as SEAP expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595026(CHEMBL5179453)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human TLR4 expressed in HEK293-Blue hTLR4 cells assessed as SEAP expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595027(CHEMBL5208041)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human TLR4 expressed in HEK293-Blue hTLR4 cells assessed as SEAP expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed