Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50016054
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591808(CHEMBL5207397)
Affinity DataIC50: 37nMAssay Description:Inhibition of mouse GAT-1 assessed as inhibition of GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591807(CHEMBL5178760)
Affinity DataIC50: 52nMAssay Description:Inhibition of mouse GAT-1 assessed as inhibition of GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 132nMAssay Description:Inhibition of mouse GAT-1 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591809(CHEMBL5203365)
Affinity DataIC50: 166nMAssay Description:Inhibition of mouse GAT-1 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human GAT-3 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276022(CHEMBL4126078)
Affinity DataIC50: 5.78E+3nMAssay Description:Inhibition of mouse GAT-4 assessed as inhibition of [3H]GABA uptake by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of rat GAT-2 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591810(CHEMBL5174502)
Affinity DataIC50: 4.47E+4nMAssay Description:Inhibition of mouse GAT-1 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent betaine transporter(Mouse)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591811(CHEMBL5187915)
Affinity DataIC50: 5.25E+4nMAssay Description:Inhibition of mouse GAT-2 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591811(CHEMBL5187915)
Affinity DataIC50: 7.24E+4nMAssay Description:Inhibition of mouse GAT-1 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent betaine transporter(Mouse)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591810(CHEMBL5174502)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse GAT-2 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent betaine transporter(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of human BGT-1 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human GAT-1 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591808(CHEMBL5207397)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to mouse GAT-1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591807(CHEMBL5178760)
Affinity DataKi:  8.90nMAssay Description:Binding affinity to mouse GAT-1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591806(CHEMBL5205864)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]-GABA uptake at GAT-1 in rat forebrain synaptosomes assessed as inhibition constant preincubated for 8 mins followed by [3H]-GABA a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataKi:  37nMAssay Description:Binding affinity to mouse GAT-1 expressed in human HEK293 cells assessed as inhibition constant in presence of NO711 marker by competitive binding as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591809(CHEMBL5203365)
Affinity DataKi:  79nMAssay Description:Binding affinity to mouse GAT-1 expressed in human HEK293 cells assessed as inhibition constant in presence of NO711 marker by competitive binding as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed