Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50015722
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of 6xHis-tagged full-length wild-type AKT1 (unknown origin) expressed in baculovirus infected Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US9434697, 108 | US9730931, Compound 108 | US10537...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FGFR4 (447 to 753 residues) incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441)
Affinity DataIC50: 3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50233461(CHEMBL4068896)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST-fused human FGFR4 (460 to 802 residues) expressed in baculovirus expression system by enzymatic methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant CDK13/Cyclin K (unknown origin) expresssed in baculovirus infected insect cells using peptide substrate incubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM316639(US9617258, Example 130 | US11111242, Example 130)
Affinity DataIC50: 75nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 12(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50: 158nMAssay Description:Inhibition of recombinant CDK12/Cyclin K (unknown origin) expresssed in baculovirus infected insect cells using peptide substrate incubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US9434697, 108 | US9730931, Compound 108 | US10537...)
Affinity DataIC50: 320nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US9434697, 108 | US9730931, Compound 108 | US10537...)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of His-tagged recombinant human FGFR1 (308 to 731 residues) expressed in baculovirus expression system using Lance ULight poly-GT as subst...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US9434697, 108 | US9730931, Compound 108 | US10537...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of His/TEV-tagged FGFR4 (447 to 753 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using Lance ULight poly-...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of recombinant full length human CDK7/C-terminal His-tagged Cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus in Sf21 insect ce...More data for this Ligand-Target Pair
In DepthDetails
PubMed