Compile Data Set for Download or QSAR
Report error Found 97 Enz. Inhib. hit(s) with all data for entry = 50018517
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609054(CHEMBL5275893)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 180 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570171(CHEMBL4870713)
Affinity DataEC50:  9.10nMAssay Description:Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609060(CHEMBL5290019)
Affinity DataEC50:  26nMAssay Description:Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609059(CHEMBL5268163)
Affinity DataEC50:  142nMAssay Description:Agonist activity at FXR in HEK293T cells incubated for 24 hrs by Steady-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609058(CHEMBL5269850)
Affinity DataEC50:  205nMAssay Description:Agonist activity at FXR in HEK293T cells incubated for 24 hrs by Steady-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609057(CHEMBL5278385)
Affinity DataEC50: <1nMAssay Description:Agonist activity at human FXR in expressed in CHO cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM532160(US11208418, Example 7)
Affinity DataEC50:  7.40nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 15 mins by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM532159(US11208418, Example 6)
Affinity DataEC50:  2nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 15 mins by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM532158(US11208418, Example 3)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 15 mins by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM532112(US11208418, Example 1)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 15 mins by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609056(CHEMBL5273044)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 180 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609055(CHEMBL5266961)
Affinity DataEC50:  27nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 180 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50570146(CHEMBL4860451)
Affinity DataEC50:  10nMAssay Description:Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609053(CHEMBL5268480)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin) incubated for 180 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609052(CHEMBL5279886)
Affinity DataEC50: <100nMAssay Description:Agonist activity at FXR in HEK293T cells by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609051(CHEMBL5270877)
Affinity DataEC50: <100nMAssay Description:Agonist activity at FXR in HEK293T cells by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609050(CHEMBL5281106)
Affinity DataEC50: <100nMAssay Description:Agonist activity at FXR in HEK293T cells by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50535382(CHEMBL4588863)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at FXR in human HepG2 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50544035(CHEMBL4643503)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human FXR by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50544034(CHEMBL4642141)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human FXR by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50544033(CHEMBL4632854)
Affinity DataEC50:  64nMAssay Description:Agonist activity at human FXR by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50544032(CHEMBL4643030)
Affinity DataEC50:  44nMAssay Description:Agonist activity at human FXR by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609012(CHEMBL5271527)
Affinity DataEC50: <30nMAssay Description:Agonist activity at human FXRMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609048(CHEMBL5278159)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human GST-tagged FXR incubated for 1 hrs by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609070(CHEMBL5273108)
Affinity DataEC50:  3.50E+3nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609074(CHEMBL5278743)
Affinity DataEC50:  420nMAssay Description:Agonist activity at TGR5 (unknown origin) expressed in CHO cells incubated for 0.5 hr by microplate reader based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609074(CHEMBL5278743)
Affinity DataEC50:  190nMAssay Description:Agonist activity at human FXR expressed in CHO cells incubated for 22 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50545816(CHEMBL4633499)
Affinity DataEC50:  1.50E+6nMAssay Description:Agonist activity at human PPARdelta expressed in HEK293T cells incubated for 12 to 14 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50545815(CHEMBL4632533)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at human PPARdelta expressed in HEK293T cells incubated for 12 to 14 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609073(CHEMBL5272705)
Affinity DataEC50:  2.40E+3nMAssay Description:Agonist activity at human PPARdelta expressed in HEK293T cells incubated for 12 to 14 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609072(CHEMBL5272000)
Affinity DataEC50:  270nMAssay Description:Agonist activity at human PPARdelta expressed in HEK293T cells incubated for 12 to 14 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50545816(CHEMBL4633499)
Affinity DataEC50:  9.40E+5nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50545815(CHEMBL4632533)
Affinity DataEC50:  800nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609073(CHEMBL5272705)
Affinity DataEC50:  230nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609072(CHEMBL5272000)
Affinity DataEC50:  300nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609071(CHEMBL5283234)
Affinity DataEC50:  1.10E+4nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609049(CHEMBL5287502)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human GST-tagged FXR incubated for 1 hrs by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609069(CHEMBL5281274)
Affinity DataEC50:  260nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609068(CHEMBL5288227)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human FXR incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609067(CHEMBL5280183)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity at human FXR incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609066(CHEMBL5274488)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human FXR incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609065(CHEMBL5288616)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human FXR incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609064(CHEMBL5286559)
Affinity DataEC50:  97nMAssay Description:Agonist activity at GST-tagged FXR (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609063(CHEMBL5282289)
Affinity DataEC50:  112nMAssay Description:Agonist activity at GST-tagged FXR (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609062(CHEMBL5271104)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609061(CHEMBL5269567)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609020(CHEMBL5266567)
Affinity DataEC50: <30nMAssay Description:Agonist activity at FXR in HEK293T cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609030(CHEMBL5281263)
Affinity DataEC50:  10nMAssay Description:Agonist activity at FXR in HEK293T cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609029(CHEMBL5276532)
Affinity DataEC50:  13nMAssay Description:Agonist activity at FXR in HEK293T cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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