Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50016401
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594724(CHEMBL5193247)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50187690(CHEMBL3827088)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human ATXMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594724(CHEMBL5193247)
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubated for 45 mins in presence of ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594727(CHEMBL5192572)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594724(CHEMBL5193247)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594717(CHEMBL5173070)
Affinity DataIC50: 18nMAssay Description:Inhibition of N-terminal GST-tagged recombinant wild type human FGFR1 (398 to 822 residues) expressed in baculovirus infected Sf21 cells incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594726(CHEMBL5207327)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594718(CHEMBL5182231)
Affinity DataIC50: 36nMAssay Description:Inhibition of human EGFR expressed in baculovirus expression system using CAGAGAIETDKEYYTVKD as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594719(CHEMBL5186583)
Affinity DataIC50: 39nMAssay Description:Inhibition of GST-tagged EGFR (unknown origin) assessed as phosphorylation level using biotinylated peptide as substrate in presence of ATP by HTScan...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594717(CHEMBL5173070)
Affinity DataIC50: 43nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human EGFR (669 to 1210 residues) L858R/T790M double mutant expressed in baculovirus infected Sf21 ce...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594726(CHEMBL5207327)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594718(CHEMBL5182231)
Affinity DataIC50: 52nMAssay Description:Inhibition of human IGF1R expressed in baculovirus expression system using poly GT peptide as substrate preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594718(CHEMBL5182231)
Affinity DataIC50: 66nMAssay Description:Inhibition of human EGFR T790M mutant expressed in baculovirus expression system using CAGAGAIETDKEYYTVKD as substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594727(CHEMBL5192572)
Affinity DataIC50: 80nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by caliper mobility shift assa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 85nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594722(CHEMBL5193175)
Affinity DataIC50: 94nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 1 hr by Z-lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594721(CHEMBL5202119)
Affinity DataIC50: 97nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 1 hr by Z-lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHepatocyte growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594723(CHEMBL5203758)
Affinity DataIC50: 101nMAssay Description:Inhibition of c-MET (unknown origin) incubated for 1 hr by Z-lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594724(CHEMBL5193247)
Affinity DataIC50: 103nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50548085(CHEMBL4792279)
Affinity DataIC50: 186nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 30 mins in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594723(CHEMBL5203758)
Affinity DataIC50: 195nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 1 hr by Z-lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50548085(CHEMBL4792279)
Affinity DataIC50: 254nMAssay Description:Inhibition of HER2 (unknown origin) preincubated for 5 mins followed by substrate peptide and ATP addition measured after 30 mins by horseradish pero...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHepatocyte growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594721(CHEMBL5202119)
Affinity DataIC50: 518nMAssay Description:Inhibition of c-MET (unknown origin) incubated for 1 hr by Z-lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHepatocyte growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594722(CHEMBL5193175)
Affinity DataIC50: 595nMAssay Description:Inhibition of c-MET (unknown origin) incubated for 1 hr by Z-lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594725(CHEMBL5188857)
Affinity DataIC50: 597nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594725(CHEMBL5188857)
Affinity DataIC50: 908nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594717(CHEMBL5173070)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant wild type human EGFR (669 to 1210 residues) expressed in baculovirus infected Sf21 cells incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase A(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of AURKA (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubated for 45 mins in presence of ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 40 mins by Kinase-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase CSK(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594728(CHEMBL5169900)
Affinity DataIC50: 5.16E+3nMAssay Description:Inhibition of CSK (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 40 mins by Kinase-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594728(CHEMBL5169900)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of EGFR (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594720(CHEMBL5194946)
Affinity DataKi:  81nMAssay Description:Binding affinity to GST-tagged human recombinant PDFGR beta expressed in baculovirus infected Sf9 insect cells assessed as inhibition constant using ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594720(CHEMBL5194946)
Affinity DataKi:  170nMAssay Description:Binding affinity to GST-tagged human recombinant EGFR expressed in baculovirus infected Sf9 insect cells assessed as inhibition constant using poly(G...More data for this Ligand-Target Pair
In DepthDetails
PubMed