Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50018666
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50519618(CHEMBL4465718)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610927(CHEMBL5266234)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human CA9 using 4-nitrophenylacetate as substrate by esterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610933(CHEMBL5268165)
Affinity DataIC50: 10nMAssay Description:Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50548033(CHEMBL4743670)
Affinity DataIC50: 29nMAssay Description:Inhibition of LSD1 (unknown origin) incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human CA9 using 4-nitrophenylacetate as substrate by esterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50519616(CHEMBL4449176)
Affinity DataIC50: 40nMAssay Description:Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610925(CHEMBL5281289)
Affinity DataIC50: 70nMAssay Description:Inhibition of human aromatase preincubated with NADPH regenerating system for 10 mins followed by substrate addition by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610926(CHEMBL5279885)
Affinity DataIC50: 740nMAssay Description:Inhibition of carbonic anhydrase 9 (unknown origin) using 4-nitrophenylacetate as substrate by UV/visible spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610932(CHEMBL5276766)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50587654(CHEMBL5181796)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10857(aromatic sulfonamide compound 5 | CHEMBL21 | 4-ami...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant human CA9 using 4-nitrophenylacetate as substrate by esterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDNA topoisomerase 1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610934(CHEMBL5281282)
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of topoisomerase 1 (unknown origin) assessed as relaxation of supercoiled kDNA incubated for 30 mins ethidium bromide staining based UV tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM81920(p-Hydroxy-benzene derivative, 3a)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human CA9 using 4-nitrophenylacetate as substrate by esterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50519618(CHEMBL4465718)
Affinity DataKi:  0.140nMAssay Description:Binding affinity to Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50519617(CHEMBL4560418)
Affinity DataKi:  50nMAssay Description:Binding affinity to Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50514200(US10703733, Comparative Example 1 | CHEMBL4446378)
Affinity DataKi:  60nMAssay Description:Binding affinity to Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50588843(CHEMBL5185054)
Affinity DataKi:  89nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50134574(CHEMBL3746042)
Affinity DataKi:  89nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610931(CHEMBL5273577)
Affinity DataKi:  120nMAssay Description:Inhibition of FITC-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610929(CHEMBL5271820)
Affinity DataKi:  260nMAssay Description:Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610928(CHEMBL5280830)
Affinity DataKi:  350nMAssay Description:Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610929(CHEMBL5271820)
Affinity DataKi:  410nMAssay Description:Inhibition of fluorescent-labeled BID-BH3 peptide binding to Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610930(CHEMBL5276025)
Affinity DataKi:  430nMAssay Description:Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) incubated for 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM23223(Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydrox...)
Affinity DataKi:  450nMAssay Description:Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) incubated for 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50610928(CHEMBL5280830)
Affinity DataKi:  450nMAssay Description:Inhibition of fluorescent-labeled BID-BH3 peptide binding to Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed