Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50018664
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of BTK C481S mutant (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Yes(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM291388((R)-1-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-...)
Affinity DataIC50: 0.5nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US9987276, Compou...)
Affinity DataIC50: 0.700nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM389631(US9951056, Example 3 | 6-(1-acryloylpiperidin-4-yl...)
Affinity DataIC50: 1.60nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50588021(CHEMBL4303247)
Affinity DataIC50: 1.90nMAssay Description:Reversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: 2.20nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein-tyrosine kinase 6(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610908(CHEMBL5271514)
Affinity DataIC50: 2.5nMAssay Description:Competitive inhibition of recombinant human BTK incubated for 10 mins in the presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US9758524, Example 6 | U...)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601461(CHEMBL5203118)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of BTK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610912(CHEMBL5288995)
Affinity DataIC50: 5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Tec(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Tec(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US9987276, Compou...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610913(CHEMBL5289623)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601462(CHEMBL5200275)
Affinity DataIC50: 7nMAssay Description:Inhibition of BTK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601451(CHEMBL5172511)
Affinity DataIC50: 18nMAssay Description:Inhibition of BTK (unknown origin) incubated for 60 mins in the presence of ATP by ADP-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601456(CHEMBL5202915)
Affinity DataIC50: 27nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601461(CHEMBL5203118)
Affinity DataIC50: 29nMAssay Description:Inhibition of wildtype EGFR (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601457(CHEMBL5206407)
Affinity DataIC50: 36nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610914(CHEMBL5272842)
Affinity DataIC50: 39nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610918(CHEMBL5270006)
Affinity DataIC50: 40nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601452(CHEMBL5185980)
Affinity DataIC50: 42nMAssay Description:Inhibition of BTK (unknown origin) incubated for 60 mins in the presence of ATP by ADP-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601462(CHEMBL5200275)
Affinity DataIC50: 47nMAssay Description:Inhibition of wildtype EGFR (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610915(CHEMBL5282968)
Affinity DataIC50: 50nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601454(CHEMBL5183488)
Affinity DataIC50: 75nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Tec(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 78nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610911(CHEMBL5172091)
Affinity DataIC50: 80nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610919(CHEMBL5289797)
Affinity DataIC50: 90nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610916(CHEMBL5274913)
Affinity DataIC50: 110nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 200nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50: 580nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610917(CHEMBL5285367)
Affinity DataIC50: 600nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610918(CHEMBL5270006)
Affinity DataIC50: 660nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610919(CHEMBL5289797)
Affinity DataIC50: 900nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Lck(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610916(CHEMBL5274913)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610917(CHEMBL5285367)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610913(CHEMBL5289623)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US9987276, Compou...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50610913(CHEMBL5289623)
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase SYK(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed