Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50018278
TargetBile acid receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataEC50:  20nMAssay Description:Inhibition of FXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBile acid receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50569591(CHEMBL4854082)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human FXRMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410545(CHEMBL5289089)
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at H3R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAromatase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM10016(4-{[(4-bromophenyl)methyl](4H-1,2,4-triazol-4-yl)a...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of aromatase in human JEG-3 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAromatase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM10020(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of aromatase in human JEG-3 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistamine H3 receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at H3R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410546(CHEMBL26159)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50109171([(S)-1-((S)-1-Methyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataIC50: 3nMAssay Description:Inhibition of cathepsin L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human sEHMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThromboxane-A synthase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410550(CHEMBL5270846)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of TXA2 synthetase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium-dependent serotonin transporter(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410553(CHEMBL5265846)
Affinity DataIC50: 6nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM436576(US10590140, Example 352 | (S)-2-amino-9-methyl- 6-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSteryl-sulfatase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of STS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410549(CHEMBL556716)
Affinity DataIC50: 8nMAssay Description:Inhibition of human sEHMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 13nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410553(CHEMBL5265846)
Affinity DataIC50: 14nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50109169((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-1-((S)-1-met...)
Affinity DataIC50: 15nMAssay Description:Inhibition of cathepsin L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50109169((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-1-((S)-1-met...)
Affinity DataIC50: 25nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVitamin D3 receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410547(CHEMBL5280769)
Affinity DataIC50: 32nMAssay Description:Agonist activity at VDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSteryl-sulfatase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM10020(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 39nMAssay Description:Inhibition of STS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium-dependent serotonin transporter(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410552(CHEMBL5269984)
Affinity DataIC50: 42nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 48nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetVitamin D3 receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410548(CHEMBL5272411)
Affinity DataIC50: 87nMAssay Description:Inhibition of VDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410552(CHEMBL5269984)
Affinity DataIC50: 101nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 170nMAssay Description:Inhibition of src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50282192(CHEMBL4163321)
Affinity DataIC50: 320nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThromboxane-A synthase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50003795(5-[Pyridin-3-yl-(3-trifluoromethyl-phenyl)-methyle...)
Affinity DataIC50: 500nMAssay Description:Inhibition of TXA2 synthetase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50109171([(S)-1-((S)-1-Methyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cathepsin L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmyloid-beta precursor protein(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410545(CHEMBL5289089)
Affinity DataIC50: 2.85E+3nMAssay Description:Inhibition of amyloid beta (1 to 42 ) (unknown origin) self aggregationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50282192(CHEMBL4163321)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50: 4.15E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmyloid-beta precursor protein(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410543(CHEMBL88041)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of amyloid beta (1 to 42 ) (unknown origin) self aggregationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50410554(CHEMBL5273513)
Affinity DataKi:  11nMAssay Description:Binding affinity to calcium channel alpha2delta1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM436576(US10590140, Example 352 | (S)-2-amino-9-methyl- 6-...)
Affinity DataKi:  454nMAssay Description:Binding affinity to calcium channel alpha2delta1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed