Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50015357
TargetRas-related C3 botulinum toxin substrate 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391238(CHEMBL5277596)
Affinity DataEC50:  8.30E+3nMAssay Description:Inhibition of Rac1 in human HPAF-II cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391239(CHEMBL1404260)
Affinity DataEC50:  2.24E+4nMAssay Description:Inhibition of Rac1 in human HPAF-II cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391240(CHEMBL496240 | CHEBI:76228)
Affinity DataEC50:  574nMAssay Description:Inhibition of Rac1 in human HeLa cells by Flow cytometric G-trap effector binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391240(CHEMBL496240 | CHEBI:76228)
Affinity DataEC50:  1.07E+3nMAssay Description:Inhibition of Cdc42 in human HeLa cells by Flow cytometric G-trap effector binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM12576(JMC515594 Compound 64 | Risdronate | CHEMBL923 | R...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant FPP synthase expressed in Escherichia coli S100 using FPP and IPP as substrates preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human FPPS expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins in presence compound by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391236(CHEMBL5276748)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK2 (unknown origin) by Kinase-glo Luminescent Kinase AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391229(CHEMBL5285501)
Affinity DataIC50: 17nMAssay Description:Inhibition of human FPPS by LC-MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM12577({1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonoprop...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant FPP synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391230(CHEMBL5276276)
Affinity DataIC50: 24nMAssay Description:Inhibition of human FPPS by LC-MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391233(CHEMBL5082037)
Affinity DataIC50: 45nMAssay Description:Inhibition of GGPP synthase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50382684(CHEMBL2023158 | US9409868, 24)
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant ROCK2 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391237(CHEMBL5290216)
Affinity DataIC50: 80nMAssay Description:Inhibition of Cdc42 GTPase in human breast cancer cell line treated for 24 hrs by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM36511(CID46398842 | 5-((2-Carboxy-1H-benzo[g]indol-1-yl)...)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human N- terminal His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391232(CHEMBL5275415)
Affinity DataIC50: 82nMAssay Description:Inhibition of GGPP synthase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391237(CHEMBL5290216)
Affinity DataIC50: 100nMAssay Description:Inhibition of Rac1 GTPase in human breast cancer cell line treated for 24 hrs by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50382684(CHEMBL2023158 | US9409868, 24)
Affinity DataIC50: 122nMAssay Description:Inhibition of human recombinant ROCK1 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 158nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGeranylgeranyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391231(CHEMBL5272025)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human GST-tagged GGPP synthase expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins in presence compound follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391234(CHEMBL5282126)
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant GGPP synthase using FPP and IPP as substrates preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM25313((4-amino-1-hydroxy-1-phosphonobutyl)phosphonic aci...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human recombinant FPP synthase expressed in Escherichia coli S100 using FPP and IPP as substrates preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM12581(JMC515594 Compound 62 | (3-amino-1-hydroxy-1-phosp...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant FPP synthase expressed in Escherichia coli S100 using FPP and IPP as substrates preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGeranylgeranyl transferase type-2 subunit alpha(Rat)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391242(CHEMBL5276821)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of rat Geranylgeranyl transferase type-2 assessed as inhibition of Rab geranylgeranylation by fluorometric Rab prenylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391241(CHEMBL1221574)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of Geranylgeranyl transferase type-2 in human NIH3T3 cells assessed as inhibition of Rab geranylgeranylation incubated for 48 hrs by immun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of human PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50391235(CHEMBL3216441)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Rac1 GTPase in human MDA-MB-435 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of human PKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM50468262(CHEMBL4277903)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of Rac1 GTPase in human MDA-MB-231 cells assessed as inhibition of cell proliferation treated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  220nMAssay Description:Binding affinity to ROCK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataKi:  300nMAssay Description:Binding affinity to ROCK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Lodz University of Technology

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataKi:  330nMAssay Description:Binding affinity to human ROCK1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)