Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50017393
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GST-tagged human SIK2 autophosphorylation measured after 30 mins in presence of [gamma33P]ATP by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601534(CHEMBL4539742)
Affinity DataIC50: 1nMAssay Description:Inhibition of SIK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of GST-tagged human SIK2 autophosphorylation measured after 30 mins in presence of [gamma33P]ATP by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601534(CHEMBL4539742)
Affinity DataIC50: 6nMAssay Description:Inhibition of SIK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601534(CHEMBL4539742)
Affinity DataIC50: 21nMAssay Description:Inhibition of SIK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 22nMAssay Description:Inhibition of human SIK3 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 41nMAssay Description:Inhibition of human PAK2 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 48nMAssay Description:Inhibition of human SIK2 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 55nMAssay Description:Inhibition of human SIK1 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 140nMAssay Description:Inhibition of human PAK3 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 210nMAssay Description:Inhibition of human MAP4K5 (KHS1) by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 250nMAssay Description:Inhibition of human NLK by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 516nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK1 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 580nMAssay Description:Inhibition of human PAK1 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 830nMAssay Description:Inhibition of human MAP2K4 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 920nMAssay Description:Inhibition of GST fused recombinant SIK1 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase N3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human PKN3 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human MST4 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human MELK by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human TIE2 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of full length C-terminal nanoLuc-tagged human NLK expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of full length C-terminal nanoLuc-tagged human TIE2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of GST fused recombinant SIK2 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase N3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of full length C-terminal nanoLuc-tagged human PKN3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601537(CHEMBL5194644)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601539(CHEMBL5189489)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of GST fused recombinant SIK3 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase kinase 5(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of full length C-terminal nanoLuc-tagged human MAP4K5 (KHS1) expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601540(CHEMBL5194766)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of full length nanoLuc-tagged human MST4 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192716(YKL-05-099 (5) | US11725011, Compound YKL-05-99)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601544(CHEMBL5175296)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601540(CHEMBL5194766)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601545(CHEMBL5187267)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601535(CHEMBL5180834)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601542(CHEMBL5169576)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601536(CHEMBL5200656)
Affinity DataIC50: 1.17E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601546(CHEMBL5179229)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 1.27E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601539(CHEMBL5189489)
Affinity DataIC50: 1.39E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601541(CHEMBL5193137)
Affinity DataIC50: 1.53E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601537(CHEMBL5194644)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataIC50: 3.09E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM192716(YKL-05-099 (5) | US11725011, Compound YKL-05-99)
Affinity DataIC50: 3.44E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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