Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50015627
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458062(CHEMBL4209019)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587892(CHEMBL5207949)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of EGFR (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50458062(CHEMBL4209019)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587890(CHEMBL5187169)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50561282(CHEMBL4780534)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using TMB as substrate incubated for 3 hrs in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587889(CHEMBL5196024)
Affinity DataIC50: 28nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587896(CHEMBL5196209)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using Poly-(Glu,Tyr 4:1) peptide as a substrate in presence of ATP by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587893(CHEMBL5203640)
Affinity DataIC50: 88nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587895(CHEMBL5198368)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using Poly-(Glu,Tyr 4:1) peptide as a substrate in presence of ATP by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using Poly-(Glu,Tyr 4:1) peptide as a substrate in presence of ATP by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587894(CHEMBL5187375)
Affinity DataIC50: 180nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 30 min in presence of ATP by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587886(CHEMBL5201387)
Affinity DataIC50: 180nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587897(CHEMBL5206805)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant C-terminal His-tagged/N-terminal GST-tagged human EGFR expressed in sf9 insect cells using poly(Glu, Tyr) sodium salt (4:1,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587887(CHEMBL5175924)
Affinity DataIC50: 220nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587894(CHEMBL5187375)
Affinity DataIC50: 250nMAssay Description:Inhibition of ErbB2 (unknown origin) pre-incubated for 5 mins followed by substrate addition and measured after 30 mins in presence of ATP by microti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587888(CHEMBL5208349)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50587888(CHEMBL5208349)
Affinity DataIC50: 1.91E+5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed