Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50017380
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50154391(CHEMBL3775257)
Affinity DataEC50:  88nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKd:  6.80E+6nMAssay Description:Binding affinity to human Notum (S81 to T451 residues) Cys330Ser mutant expressed in human HEK293T cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataKd:  8.50E+4nMAssay Description:Binding affinity to human Notum (S81 to T451 residues) Cys330Ser mutant expressed in human HEK293T cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataEC50:  4.58E+4nMAssay Description:Inhibition of human Notum (S81 to T451 residues) Cys330Ser mutant in human HEK293 cells expressing Renilla and STF reporter gene and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSegment polarity protein dishevelled homolog DVL-1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50601473(CHEMBL5170789)
Affinity DataKd:  3.45E+4nMAssay Description:Binding affinity to recombinant human Dvl1 PDZ domain assessed as chemical shift change by 1H-15N HSQC NMR spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSegment polarity protein dishevelled homolog DVL-1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50177679(CHEMBL3814761)
Affinity DataKd:  9.54E+5nMAssay Description:Binding affinity to recombinant human Dvl1 PDZ domain assessed as chemical shift change by 1H-15N HSQC NMR spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50144578(CHEMBL3760062)
Affinity DataEC50:  12nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50154387(CHEMBL3774528)
Affinity DataEC50:  157nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataEC50:  23nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50144578(CHEMBL3760062)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50154387(CHEMBL3774528)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM601033(1-[2,4-dichloro-3-(trifluoromethyl)phenyl]triazole...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50589392(Lorecivivint | Adavivint | Sm04690 | SM-04690 | SM...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50589392(Lorecivivint | Adavivint | Sm04690 | SM-04690 | SM...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DYRK1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50601475(CHEMBL4539054)
Affinity DataIC50: 32nMAssay Description:Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50539249(CHEMBL4441123)
Affinity DataIC50: 85nMAssay Description:Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50601474(CHEMBL4439414)
Affinity DataIC50: 120nMAssay Description:Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50361164(CHEMBL4174188)
Affinity DataIC50: 170nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50601477(CHEMBL4580274)
Affinity DataIC50: 210nMAssay Description:Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50601476(CHEMBL4465711)
Affinity DataIC50: 680nMAssay Description:Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of human Notum (81 to T451 residues) Cys330Ser mutant using OPTS substrate incubated for 16 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50601478(CHEMBL4470075)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Notum using OPTS substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50471827(CHEMBL284521)
Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 7.54E+4nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM29612(N-Acetyltryptamine,5-Hydroxy | CHEMBL33103 | Norme...)
Affinity DataIC50: 9.36E+4nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed