Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50018238
TargetSerine/threonine-protein kinase ULK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50271371(CHEMBL4125718)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GST-tagged ULK1 incubated for 20 mins by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity protein kinase TTK(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM532292(JGS79C | N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-m...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human TTK by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human SRC by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407812(Kw-2450 | KW-2450)
Affinity DataIC50: 2nMAssay Description:Inhibition of human IGF1R expressed in SUM149 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407812(Kw-2450 | KW-2450)
Affinity DataIC50: 2nMAssay Description:Inhibition of human IGF1R expressed in MDA-MB-468 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 2nMAssay Description:Inhibition of human SRC incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK4 incubated for 18 hrs by microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Akt1 by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human mTOR by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetGamma-secretase-activating protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human gamma secretase by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human ErbB2More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK2 (unknown origin) by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human cdc7 incubation of 30 mins in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CDK6 incubated for 18 hrs by microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM148264(US8962630, 74 | Ribociclib | LEE011 | Kisqali | 7-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CDK4 incubated for 18 hrs by microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Akt2 by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 12nMAssay Description:Inhibition of human VEGFR2 incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50407809(CHEMBL5095897)
Affinity DataIC50: 13nMAssay Description:Inhibition of human DYRK2More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 19nMAssay Description:Inhibition of human CRAF incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 22nMAssay Description:Inhibition of human BRAF incubated for 40 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK1 (unknown origin) by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human CDK9 incubation of 30 mins in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 6(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM148264(US8962630, 74 | Ribociclib | LEE011 | Kisqali | 7-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human CDK6 incubated for 18 hrs by microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50: 50nMAssay Description:Inhibition of p110 alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human Akt3 by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407812(Kw-2450 | KW-2450)
Affinity DataIC50: 66nMAssay Description:Inhibition of human Aurora B kinase expressed in MDA-MB-231 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50536941(CHEMBL4521985)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant PARP1 incubated for 60 mins by PARP assay kit methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4 (unknown origin) by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50: 116nMAssay Description:Inhibition of p110 delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50: 166nMAssay Description:Inhibition of p110 beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK2 (unknown origin) by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase A(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407812(Kw-2450 | KW-2450)
Affinity DataIC50: 215nMAssay Description:Inhibition of human Aurora A kinase expressed in MDA-MB-468 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50380363(CHEMBL2017974 | US10173995, Compound 1)
Affinity DataIC50: 262nMAssay Description:Inhibition of p110 gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407812(Kw-2450 | KW-2450)
Affinity DataIC50: 272nMAssay Description:Inhibition of human Aurora B kinase expressed in SUM149 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407812(Kw-2450 | KW-2450)
Affinity DataIC50: 478nMAssay Description:Inhibition of human Aurora B kinase expressed in MDA-MB-468 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 500nMAssay Description:Inhibition of BET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human JAK2 by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human JAK1 by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407810(CHEMBL5289804)
Affinity DataIC50: 3.23E+3nMAssay Description:Inhibition of human SRC by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic elongation factor 2 kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of eEF2K (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetThioredoxin(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407811(CHEMBL5290420)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TXN incubated for 30 mins by fluorescence based plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50396022(CHEMBL2169920)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human SMYD2 by western blot assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-8(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human IL-8 by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human MCL1More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of CDK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of CDK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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