Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50015598
TargetCasein kinase I isoform alpha(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataKd:  1nMAssay Description:Binding affinity to CK1alpha (unknown origin) using casein as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of cMET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50524300(LY2606368 | Prexasertib | US11564920, Example Prex...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM162989(US9056865, A-116)
Affinity DataIC50: 5.80nMAssay Description:Binding affinity to human SMO (181 to 787 residues) expressed in human HEK293 cells assessed as radioactivity incubated for 2 hrs in presence of H3-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo-HCl | US9221808, 1bo-Mes | US922180...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 8nMAssay Description:Inhibition of endogenous human Smo overexpressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase activity b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo-HCl | US9221808, 1bo-Mes | US922180...)
Affinity DataIC50: 15nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50: 19nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSmoothened homolog(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 27nMAssay Description:Inhibition of endogenous mouse Smo overexpressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase activity b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM31545(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)
Affinity DataIC50: 45nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50401323(CHEMBL2205230)
Affinity DataIC50: 79nMAssay Description:Inhibition of Smo D473H mutant (unknown origin) expressed in mouse NIH3T3 cells cotransfected with Gli luciferase reporter gene assessed as Gli lucif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587737(Leq 506 | Leq506 | Nvp-leq-506 | LEQ-506 | LEQ506 ...)
Affinity DataIC50: 96nMAssay Description:Antagonist activity at resistant Smo D473H mutant (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 300nMAssay Description:Inhibition of wild type Smo (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50545020(Taladegib | LY-2940680 | LY2940680)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at resistant Smo D473H mutant (unknown origin) in presence of GDC0449More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 700nMAssay Description:Inhibition of Smo D473H mutant (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human VEGFR2 (789 to 1356 residues) assessed as reduction in autophosphorylation at Y1175 residues using poly (Glu4Tyr1) peptide and AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed