Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50018232
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407718(CHEMBL5289364)
Affinity DataKd:  180nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50512415(CHEMBL4226052)
Affinity DataKd:  28nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50512415(CHEMBL4226052)
Affinity DataKd:  90nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  37nMAssay Description:Binding affinity to BRD4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407716(CHEMBL5277866)
Affinity DataKd:  44nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407717(CHEMBL5278246)
Affinity DataKd:  382nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50593635(CHEMBL5205867)
Affinity DataKd:  2nMAssay Description:Inhibition of poly His-tagged BRD4 BD2 (unknown origin) (348 to 455 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50593635(CHEMBL5205867)
Affinity DataKd:  301nMAssay Description:Inhibition of poly His-tagged BRD4 BD1 (unknown origin) (71 to 94 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  9.60nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407717(CHEMBL5278246)
Affinity DataKd:  120nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407714(CHEMBL5269983)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of poly His-tagged BRD4 BD2 (unknown origin) (348 to 455 residues) by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407715(CHEMBL5290597)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human HDAC3 using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin) after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50551271(CHEMBL4747491)
Affinity DataIC50: 22nMAssay Description:Inhibition of PLK1 (unknown origin) by radiometric ATP-competitive kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407714(CHEMBL5269983)
Affinity DataIC50: 27nMAssay Description:Inhibition of poly His-tagged BRD4 BD1 (unknown origin) (71 to 94 residues) by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50551271(CHEMBL4747491)
Affinity DataIC50: 109nMAssay Description:Inhibition of BRD4 (unknown origin) by radiometric ATP-competitive kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataIC50: 130nMAssay Description:Inhibition of 6-His tagged BRD4 BD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407713(CHEMBL5082762)
Affinity DataIC50: 163nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetALK tyrosine kinase receptor(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 190nMAssay Description:Inhibition of ALK (unknown origin) by radiometric ATP-competitive kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597849(CHEMBL5205994)
Affinity DataIC50: 379nMAssay Description:Inhibition of recombinant human BRD4 BD2 measured after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597849(CHEMBL5205994)
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant human BRD4 BD1 measured after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50407713(CHEMBL5082762)
Affinity DataIC50: 1.07E+3nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597849(CHEMBL5205994)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of PARP1 (unknown origin) using NAD+ as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) (333 to 460 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 82 | US10633379, Example 35)
Affinity DataKi:  1.60nMAssay Description:Inhibition of BRD4 BD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 82 | US10633379, Example 35)
Affinity DataKi:  520nMAssay Description:Inhibition of BRD4 BD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed