Compile Data Set for Download or QSAR
Report error Found 112 Enz. Inhib. hit(s) with all data for entry = 50018520
TargetAmyloid-beta precursor protein(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609114(CHEMBL2151086)
Affinity DataEC50:  270nMAssay Description:Inhibition of amyloid beta 42 in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmyloid-beta precursor protein(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609115(CHEMBL2151085)
Affinity DataEC50:  70nMAssay Description:Inhibition of amyloid beta 42 in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmyloid-beta precursor protein(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50114789(CHEMBL3609747)
Affinity DataEC50:  70nMAssay Description:Inhibition of amyloid beta 42 in human H4 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTumor necrosis factor(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609117(CHEMBL5275470)
Affinity DataEC50:  300nMAssay Description:Inhibition of human TNF-alpha secretion stimulated by LPSMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetRibosomal protein S6 kinase alpha-5(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM24996(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetRibosomal protein S6 kinase alpha-5(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609121(CHEMBL5276100)
Affinity DataIC50: 3nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-3(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609116(CHEMBL5280661)
Affinity DataIC50: 6nMAssay Description:Inhibition of caspase-3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50: 9nMAssay Description:Inhibition Akt3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlutathione S-transferase Mu 2(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609123(CHEMBL5275770)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GSTM2-2 expressed in Escherichia coli assessed as inhibition by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50: 13nMAssay Description:Inhibition Akt2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50310474(4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p70S6 (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50168576(3-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-pyrazin-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50509623(CHEMBL4585089)
Affinity DataIC50: 21nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 24nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-3(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 27nMAssay Description:Inhibition of caspase-3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50396763(CHEMBL2172374)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM14047(N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H...)
Affinity DataIC50: 35nMAssay Description:Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AK...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50: 39nMAssay Description:Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AK...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50396763(CHEMBL2172374)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50391772(CHEMBL2146851)
Affinity DataIC50: 42nMAssay Description:Inhibition of hERG (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-7(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609116(CHEMBL5280661)
Affinity DataIC50: 42nMAssay Description:Inhibition of caspase-7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609118(CHEMBL5282422)
Affinity DataIC50: 55nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609116(CHEMBL5280661)
Affinity DataIC50: 67nMAssay Description:Inhibition of caspase-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50235921(CHEMBL584991)
Affinity DataIC50: 67nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50465399(CHEMBL4291940)
Affinity DataIC50: 67nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50465399(CHEMBL4291940)
Affinity DataIC50: 69nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 73nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50529361(CHEMBL4515137 | US10988487, Example 52)
Affinity DataIC50: 81nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-7(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 87nMAssay Description:Inhibition of caspase-7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50: 94nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 100nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM24996(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlutathione S-transferase Mu 2(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609124(CHEMBL5289652)
Affinity DataIC50: 100nMAssay Description:Inhibition of human GSTM2-2 expressed in Escherichia coli assessed as inhibition by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50609132(CHEMBL5278835)
Affinity DataIC50: 100nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50168589(3-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-pyridin-...)
Affinity DataIC50: 107nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 110nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50396763(CHEMBL2172374)
Affinity DataIC50: 123nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-8(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 130nMAssay Description:Inhibition of caspase-8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
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