Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50013129
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataIC50: 0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataIC50: 0.0100nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM258466(US9522888, 689)
Affinity DataIC50: 0.0160nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50562873(CHEMBL4786296)
Affinity DataIC50: 0.0400nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.0700nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50562873(CHEMBL4786296)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.670nMAssay Description:Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at recombinant human S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at recombinant human S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50562873(CHEMBL4786296)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at recombinant human S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM258466(US9522888, 689)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at recombinant human S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM258466(US9522888, 689)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM258466(US9522888, 689)
Affinity DataEC50:  3.60nMAssay Description:Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataEC50:  3.60nMAssay Description:Agonist activity at recombinant human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50562873(CHEMBL4786296)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM258466(US9522888, 689)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50562873(CHEMBL4786296)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM258466(US9522888, 689)
Affinity DataEC50:  5.60nMAssay Description:Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  8.20nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50562873(CHEMBL4786296)
Affinity DataEC50:  10nMAssay Description:Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  11nMAssay Description:Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  11nMAssay Description:Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at recombinant human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50562873(CHEMBL4786296)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at recombinant human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Bristol Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM258466(US9522888, 689)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at recombinant human S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed