Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50018230
TargetProcathepsin L(Human)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50073850([(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-pr...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human Cathepsin L using Z-Phe-Arg-AMC as substrate incubated for 4 hrs by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM420297(med.21724, Compound 62 | peptidomimetic aldehydes ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant SARS-COV2 main protease using Mca-AVLQ-SGFR-Lys-NH2 as substrate by FRET based cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant SARS-COV2 main protease using Mca-AVLQ-SGFR-Lys-NH2 as substrate by FRET based cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Mouse)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50407514(CHEMBL1234732)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse ADAM17 expressed in HEK293 cells overexpressed with ACE2 assessed as inhibition of ACE2 shedding incubated for 65 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant SARS-COV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Mouse)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50407515(CHEMBL5285968)
Affinity DataIC50: 200nMAssay Description:Inhibition of mouse ADAM17 expressed in HEK293 cells overexpressed with ACE2 assessed as inhibition of ACE2 shedding incubated for 65 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM21489(MLN4760 | (2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichl...)
Affinity DataIC50: 440nMAssay Description:Inhibition of human ACE2 expressed in baculovirus in Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant SARS-COV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50407519(CHEMBL5268979)
Affinity DataIC50: 670nMAssay Description:Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50407516(CHEMBL5280512)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50431275(Mifurol | CARMOFUR | med.21724, Compound 152 | Car...)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM420293(alpha-ketoamide inhibitor 13a)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of recombinant SARS-COV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM7781(4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione ...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50407712(CHEMBL1779106)
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of recombinant Cathepsin L (unknown origin) using Z-Phe-Arg-AMC as substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM51395(tert-butyl N-[(2S)-1-[2-[2-(3,4-dihydro-2H-quinoli...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human liver Cathepsin L using Z-Phe-Arg-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50058655(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Affinity DataIC50: 9.35E+3nMAssay Description:Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50033731(5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50426071(CHEMBL406050 | US9018255, PX-12 | med.21724, Compo...)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of SARS-COV2 main protease using Mca-AVLQ-SGFR-K as substrate by Fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50374666(CHEMBL259450)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human liver Cathepsin L using Z-Phe-Arg-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50233798(N-(2-aminoethyl)-1-aziridine-ethanamine | CHEMBL39...)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of SARS-COV2 pseudotyped virus binding to human ACE2 expressed in HEK293T cells using CPRG as substrate incubated for 3 hrs followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
American University of Ras Al Khaimah

Curated by ChEMBL
LigandPNGBDBM50233798(N-(2-aminoethyl)-1-aziridine-ethanamine | CHEMBL39...)
Affinity DataKi:  4.59E+5nMAssay Description:Binding affinity to human recombinant ACE2 assessed as inhibition constant using fluorogenic peptide substrate VI incubated for 10 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed