Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 50017353
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human full length P13Kdelta expressed in Sf9 cells assessed as reduction in ATP-dependent phosphorylation by chromatography...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM188514(4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-2,4,6...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GSK3alpha (unknown origin) by ADP-glo analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601417(CHEMBL5178166)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50557487(Tolebrutinib)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50040805(CHEMBL3361255)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601417(CHEMBL5178166)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50374681(CHEMBL257834)
Affinity DataIC50: 2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant FAK (410 to 689 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBeta-adrenergic receptor kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of GRK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 5.70nMAssay Description:Reversible inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 5.90nMAssay Description:Reversible inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50505940(CHEMBL4449840)
Affinity DataIC50: 6nMAssay Description:Inhibition of ASK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50040806(CHEMBL3361254)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601414(CHEMBL5173945)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant GSK3betaMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601414(CHEMBL5173945)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50386749(CHEMBL2046883)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDC7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetKetohexokinase(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50: 10nMAssay Description:Inhibition of KHK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50443871(CHEMBL3091536)
Affinity DataIC50: 12nMAssay Description:Inhibition of human GSK3More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 15nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 17nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin) in presence of ATP at 5 uMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50256480(N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50515269(CHEMBL4462592)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50515269(CHEMBL4462592)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase SYK(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542)
Affinity DataIC50: 41nMAssay Description:Competitive inhibition of SYK (unknown origin) assessed as inhibition constant in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRho-associated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM322155(US11311541, Example SLx-2119 | US10696660, SLx-211...)
Affinity DataIC50: 60nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601417(CHEMBL5178166)
Affinity DataIC50: 79nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601418(BENTAMAPIMOD | Bentamapimod | As-602801 | AS602801...)
Affinity DataIC50: 80nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50023727(CHEMBL3330170)
Affinity DataIC50: 90nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601418(BENTAMAPIMOD | Bentamapimod | As-602801 | AS602801...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50515269(CHEMBL4462592)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 162nMAssay Description:Inhibition of human TBK1More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 169nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50056163((S)-2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamin...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50355495(CHEMBL1908391)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant c-KITMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601418(BENTAMAPIMOD | Bentamapimod | As-602801 | AS602801...)
Affinity DataIC50: 230nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 251nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataIC50: 270nMAssay Description:Inhibition of mTOR (unknown origin) activationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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