Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50015585
TargetNF-kappa-B essential modulator(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50587700(CHEMBL5171411)
Affinity DataKd:  190nMAssay Description:Binding affinity to full-length human NEMO (1 to 419 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNF-kappa-B essential modulator(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50587701(CHEMBL5180326)
Affinity DataKd:  80nMAssay Description:Binding affinity to full-length human NEMO (1 to 419 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50587702(CHEMBL5172069)
Affinity DataEC50:  730nMAssay Description:Agonist activity at RXRalpha (unknown origin) using fluorescein-D22 as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50587702(CHEMBL5172069)
Affinity DataEC50:  730nMAssay Description:Agonist activity at RXRalpha (unknown origin) using fluorescein-D22 as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50587702(CHEMBL5172069)
Affinity DataEC50:  170nMAssay Description:Agonist activity at RXRalpha (unknown origin) using fluorescein-D22 as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50587703(CHEMBL5174729)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM50519616(CHEMBL4449176)
Affinity DataIC50: 40nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM178123((2'R*,7R*)-3-(4-methoxybenzyl)-3,5,6,7-tetrahy...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM50519610(CHEMBL4533049)
Affinity DataIC50: 300nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPhosphoglycerate mutase 1(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50587704(CHEMBL5184747)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of PGAM1 in human MDA-MB-231 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMethionine aminopeptidase 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM178130((4R,7S)-3-[(4-methoxyphenyl)methyl]-3,5,6,7-tetrah...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50462118(CHEMBL4243296)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to Guinea pig brain Sigma1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50035097(CHEMBL303336 | 1''-benzylspiro[1,2,3,4-tetrahydron...)
Affinity DataKi:  2nMAssay Description:Binding affinity to Guinea pig brain Sigma1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50035097(CHEMBL303336 | 1''-benzylspiro[1,2,3,4-tetrahydron...)
Affinity DataKi:  44nMAssay Description:Binding affinity to rat liver Sigma2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50462118(CHEMBL4243296)
Affinity DataKi:  243nMAssay Description:Binding affinity to rat liver Sigma2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed