Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50015582
TargetInsulin receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587680(CHEMBL5182271)
Affinity DataKd:  12nMAssay Description:Binding affinity to human InsR expressed in mouse IGF1R knockout MEF cells assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 2(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKd:  23nMAssay Description:Binding affinity to NUAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587680(CHEMBL5182271)
Affinity DataKd:  9nMAssay Description:Binding affinity to human IGF1R expressed in mouse IGF1R knockout MEF cells assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 2(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to NUAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  13nMAssay Description:Binding affinity to NUAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587680(CHEMBL5182271)
Affinity DataIC50: 1nMAssay Description:Inhibition of human IGF1R expressed in mouse IGF1R knockout MEF cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInsulin receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587680(CHEMBL5182271)
Affinity DataIC50: 1nMAssay Description:Inhibition of human InsR expressed in mouse IGF1R knockout MEF cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587681(CHEMBL5176650)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50: 3nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 4nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587683(CHEMBL5196626)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK4 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50: 5nMAssay Description:Inhibition of human NUAK1More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 7(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK7 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 3(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK3 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK2 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK1 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM86615(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587672(CHEMBL5192992)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587682(CHEMBL5204647)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 10nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Fyn(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50: 11nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST fused recombinant SIK2 in HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser329 incubated for 1 hr in presence of ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587673(CHEMBL5175737)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587670(CHEMBL5202161)
Affinity DataIC50: 17nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50: 26nMAssay Description:Inhibition of PDGFRb (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50: 26nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587674(CHEMBL1643963)
Affinity DataIC50: 33nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587684(CHEMBL5169640)
Affinity DataIC50: 35nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50: 43nMAssay Description:Inhibition of GST fused recombinant SIK3 in HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser370 incubated for 1 hr in presence of ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 47nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 48nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50: 54nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50524300(LY2606368 | Prexasertib | US11564920, Example Prex...)
Affinity DataIC50: 64nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587676(CHEMBL5195181)
Affinity DataIC50: 67nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587671(CHEMBL4303250)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNUAK family SNF1-like kinase 2(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal GST-tagged human NUAK2 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP by cerenko...More data for this Ligand-Target Pair
In DepthDetails
PubMed
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