Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50015580
TargetBeta-secretase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM41542(US8865911, 122)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM116301(US8637504, 76 | US9273053, 76 | US9650371, 76)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | US8748451, 6 | Tubastatin A | US92...)
Affinity DataIC50: 18nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50130725(SB-415286 | cid_4210951 | 3-(3-chloro-4-hydroxyphe...)
Affinity DataIC50: 34nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 60nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 73nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 230nMAssay Description:Inhibition of AchE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50587667(CHEMBL5175467)
Affinity DataIC50: 304nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 340nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50368627(CHEMBL4160653)
Affinity DataIC50: 890nMAssay Description:Inhibition of recombinant human His6-taged GSK-3beta assessed as substrate phosphorylation incubated for 30 mins using RRRPASVPPSPSLSRHSSHQRR peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAdenosine kinase(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50484018(CHEMBL223769)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human wild type AK expressed in Escherichia coli using [2,8- 3H]-Ado and ATP as substrate by radiometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50535402(CHEMBL4449010)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50535402(CHEMBL4449010)
Affinity DataIC50: 3.19E+3nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | US8748451, 6 | Tubastatin A | US92...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50249336(CHEMBL1910509)
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of recombinant human His6-taged GSK-3beta assessed as substrate phosphorylation incubated for 30 mins using RRRPASVPPSPSLSRHSSHQRR peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50535402(CHEMBL4449010)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50587666(CHEMBL5200940)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of recombinant human GSK-3beta incubated for 30 mins using prephosphorylated polypeptide as substrate in presence of ATP by Kinase-Glo rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50587666(CHEMBL5200940)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of BACE-1 (unknown origin) using M-240 (methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl) peptide as substrate preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50580216(VERUBECESTAT | Verubecestat | MK-8931 | SCH 900931...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50510823(E-2609 | E2609 | Elenbecestat)
Affinity DataKi:  27nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed