Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50011913
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50552415(CHEMBL4749601)
Affinity DataEC50:  4.70E+3nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50552416(CHEMBL4763262)
Affinity DataEC50:  9.50E+3nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataEC50:  1.03E+4nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50552414(CHEMBL4791592)
Affinity DataEC50:  1.20E+4nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50552413(CHEMBL4780270)
Affinity DataEC50:  4.80E+3nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50552412(CHEMBL4752955)
Affinity DataEC50:  4.70E+4nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50552411(CHEMBL4762495)
Affinity DataEC50:  1.31E+5nMAssay Description:Activation of human PXR ligand binding domain incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552414(CHEMBL4791592)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50207645(CHEMBL3971179)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552408(CHEMBL4750971)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at rat TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Fluo-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552420(CHEMBL4759917)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552416(CHEMBL4763262)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552413(CHEMBL4780270)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552412(CHEMBL4752955)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552411(CHEMBL4762495)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552419(CHEMBL4785984)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552418(CHEMBL4749804)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552410(CHEMBL4795385)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552408(CHEMBL4750971)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552423(CHEMBL4748099)
Affinity DataIC50: 270nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552415(CHEMBL4749601)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552409(CHEMBL4785621)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552417(CHEMBL4758145)
Affinity DataIC50: 720nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552425(CHEMBL4786793)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552424(CHEMBL4745090)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552428(CHEMBL4764800)
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552426(CHEMBL4777635)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552427(CHEMBL4751372)
Affinity DataIC50: 2.20E+3nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552421(CHEMBL4763338)
Affinity DataIC50: 3.30E+3nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552422(CHEMBL4754910)
Affinity DataIC50: 1.95E+4nMAssay Description:Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552408(CHEMBL4750971)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human TRPA1 transfected in HEK293T cells assessed as reduction in AITC-induced calcium influx measured after 60 mins by Fluo-4 AM dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552408(CHEMBL4750971)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human TRPV1 transfected in HEK293T cells assessed as reduction in capsaicin-induced calcium influx measured after 60 mins by Fluo-4 AM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50552408(CHEMBL4750971)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human TRPV4 transfected in HEK293T cells assessed as reduction in RN1747-induced calcium influx measured after 60 mins by Fura-2 AM dye...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed