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Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50018765
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50111899(5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50061101(4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyph...)
Affinity DataIC50: 80nMAssay Description:Binding affinity to recombinant human ETAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50287546(5-(2-Ethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyraz...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50532556(CHEMBL4438132)
Affinity DataIC50: 800nMAssay Description:Binding affinity to recombinant human ETAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50532571(CHEMBL4525321)
Affinity DataIC50: 1.50E+3nMAssay Description:Binding affinity to recombinant human ETAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50612245(CHEMBL5272983)
Affinity DataIC50: 2.00E+3nMAssay Description:Binding affinity to human placenta ETBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50612246(ZAPRINAST | Zaprinast | M&B 22948 | NSC-757885)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstacyclin receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50235383(ACT-293987 | NS-304 | Selexipag | Uptravi)
Affinity DataIC50: 6.40E+3nMAssay Description:Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50612245(CHEMBL5272983)
Affinity DataIC50: 1.80E+4nMAssay Description:Binding affinity to recombinant human ETAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed