Compile Data Set for Download or QSAR
Report error Found 143 Enz. Inhib. hit(s) with all data for entry = 50011625
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataKd:  711nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)
Affinity DataKd:  569nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454519(US10717746, Example 2)
Affinity DataKd:  3.64E+3nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataKd:  0.0894nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)
Affinity DataKd:  0.123nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454519(US10717746, Example 2)
Affinity DataKd:  0.295nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454544(US10717746, Example 27)
Affinity DataEC50:  38nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454567(US10717746, Example 48)
Affinity DataEC50:  15nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549515(CHEMBL4759074)
Affinity DataEC50:  68nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549515(CHEMBL4759074)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454562(US10717746, Example 43)
Affinity DataEC50:  420nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454539(US10717746, Example 22)
Affinity DataEC50:  54nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454559(US10717746, Example 40 | US10717746, Example 41)
Affinity DataEC50:  92nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454559(US10717746, Example 40 | US10717746, Example 41)
Affinity DataEC50:  77nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454566(US10717746, Example 47)
Affinity DataEC50:  74nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454558(US10717746, Example 39)
Affinity DataEC50:  140nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataEC50:  14nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)
Affinity DataEC50:  29nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454533(US10717746, Example 16)
Affinity DataEC50:  100nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454570(US10717746, Example 51)
Affinity DataEC50:  15nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454563(US10717746, Example 44)
Affinity DataEC50:  39nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454525(US10717746, Example 8)
Affinity DataEC50:  260nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454532(US10717746, Example 15)
Affinity DataEC50:  670nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454530(US10717746, Example 13)
Affinity DataEC50:  910nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454528(US10717746, Example 11)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454584(US10717746, Example 66)
Affinity DataEC50:  180nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454529(US10717746, Example 12)
Affinity DataEC50:  700nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454527(US10717746, Example 10)
Affinity DataEC50:  330nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454524(US10717746, Example 7)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549519(CHEMBL4759053)
Affinity DataEC50:  150nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549520(CHEMBL4758821)
Affinity DataEC50:  560nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454519(US10717746, Example 2)
Affinity DataEC50:  130nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454582(US10717746, Example 63)
Affinity DataEC50:  160nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454520(US10717746, Example 3)
Affinity DataEC50:  440nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549521(CHEMBL4760601)
Affinity DataEC50:  660nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM164883(US9067888, 33)
Affinity DataEC50:  220nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454567(US10717746, Example 48)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454570(US10717746, Example 51)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454563(US10717746, Example 44)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454570(US10717746, Example 51)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA Polymerase 2 CTD phosphorylation at Ser2 residues measured after 6 hrs by immunof...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454539(US10717746, Example 22)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA Polymerase 2 CTD phosphorylation at Ser2 residues measured after 6 hrs by immunof...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549515(CHEMBL4759074)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK3 (unknown origin) in presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454597(US10717746, Example 82)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454566(US10717746, Example 47)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 23nMAssay Description:Inhibition of CDK3 (unknown origin) in presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM454584(US10717746, Example 66)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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