Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50012974
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50247128((6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazo...)
Affinity DataEC50:  22nMAssay Description:Inhibition of HIV1 3B reverse transcriptase infected in human GHOST CXCR4 cells assessed as reduction in viral replication incubated for 60 to 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561917(CHEMBL4789939)
Affinity DataEC50:  1.45E+5nMAssay Description:Inhibition of HIV1 3B reverse transcriptase infected in human GHOST CXCR4 cells assessed as reduction in viral replication incubated for 60 to 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561914(CHEMBL4784104)
Affinity DataEC50:  960nMAssay Description:Inhibition of HIV1 3B reverse transcriptase infected in human GHOST CXCR4 cells assessed as reduction in viral replication incubated for 60 to 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561914(CHEMBL4784104)
Affinity DataEC50:  50nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561915(CHEMBL4752423)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50247128((6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazo...)
Affinity DataIC50: 7.40nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human Chem-1 cells measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 8.90nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells co- expressing Gqi5 assessed as decrease in DAMGO-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50553072(CHEMBL4750948)
Affinity DataIC50: 17nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human Chem-1 cells measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561914(CHEMBL4784104)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells co- expressing Gqi5 assessed as decrease in DAMGO-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50247128((6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazo...)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at CXCR4 (unknown origin) expressed in CHO cells assessed as reduction in SDF1-induced intracellular calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561915(CHEMBL4752423)
Affinity DataIC50: 254nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells co- expressing Gqi5 assessed as decrease in DAMGO-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561914(CHEMBL4784104)
Affinity DataIC50: 3.60E+3nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human Chem-1 cells measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561914(CHEMBL4784104)
Affinity DataIC50: 8.30E+3nMAssay Description:Antagonist activity at CXCR4 (unknown origin) expressed in CHO cells assessed as reduction in SDF1-induced intracellular calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561917(CHEMBL4789939)
Affinity DataIC50: 5.30E+4nMAssay Description:Antagonist activity at CXCR4 (unknown origin) expressed in CHO cells assessed as reduction in SDF1-induced intracellular calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561917(CHEMBL4789939)
Affinity DataIC50: 6.90E+4nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human Chem-1 cells measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-NLX from mouse mu opioid receptor expressed in CHO cells measured after 1.5 hrs by competitive-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561916(CHEMBL4779258)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-NLX from mouse mu opioid receptor expressed in CHO cells measured after 1.5 hrs by competitive-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561915(CHEMBL4752423)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-NLX from mouse mu opioid receptor expressed in CHO cells measured after 1.5 hrs by competitive-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50561914(CHEMBL4784104)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-NLX from mouse mu opioid receptor expressed in CHO cells measured after 1.5 hrs by competitive-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed