Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50015716
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589142(CHEMBL5184459)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of human recombinant c-MET in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589150(CHEMBL5189340)
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589141(CHEMBL5174958)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human recombinant c-MET in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589147(CHEMBL5186748)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589150(CHEMBL5189340)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589140(CHEMBL5190707)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of c-MET (unknown origin) using FAM-labelled peptide as substrate incubated for 10 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589144(CHEMBL5208686)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589145(CHEMBL5177149)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human full length PARP1 expressed in Escherichia coli rosetta (DE3) incubated for 20 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589143(CHEMBL5174011)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human full length PARP1 expressed in Escherichia coli rosetta (DE3) incubated for 20 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50288530(CHEMBL4098253)
Affinity DataIC50: 2.80nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589154(CHEMBL5176058)
Affinity DataIC50: 4.20nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589155(CHEMBL5196674)
Affinity DataIC50: 4.70nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589152(CHEMBL5179574)
Affinity DataIC50: 7nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589153(CHEMBL5185911)
Affinity DataIC50: 8.20nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589157(CHEMBL5180625)
Affinity DataIC50: 12nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589159(CHEMBL5195527)
Affinity DataIC50: 16nMAssay Description:Inhibition of PARP1 (unknown origin) by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589160(CHEMBL5186944)
Affinity DataIC50: 33nMAssay Description:Inhibition of BTK (unknown origin) incubated for 30 mins in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589151(CHEMBL5202615)
Affinity DataIC50: 37nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589156(CHEMBL5186314)
Affinity DataIC50: 44nMAssay Description:Displacement of [125I]KX1 from PARP1 in human OVCAR-8 cells incubated for 1 hr by wizard gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589158(CHEMBL5181382)
Affinity DataIC50: 46nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 30 mins by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589152(CHEMBL5179574)
Affinity DataIC50: 57nMAssay Description:Inhibition of HDAC6 (unknown origin) measured after 15 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589146(CHEMBL5202124)
Affinity DataIC50: 61nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50536938(CHEMBL4521684)
Affinity DataIC50: 97nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589163(CHEMBL5181360)
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 5 mins in presence of ATP by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589164(CHEMBL5204637)
Affinity DataIC50: 310nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 5 mins in presence of ATP by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589162(CHEMBL5208660)
Affinity DataIC50: 910nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 5 mins in presence of ATP by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589148(CHEMBL5187847)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589149(CHEMBL5205255)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly (Glu, Tyr) substrate incubated for 40 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589161(CHEMBL5187237)
Affinity DataIC50: 1.07E+5nMAssay Description:Inhibition of c-Met (unknown origin) incubated for 20 to 30 mins in presence of [33P]-ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 1(Human)
Key Laboratory of Technology of Drug Preparation (Zhengzhou University)

Curated by ChEMBL
LigandPNGBDBM50589148(CHEMBL5187847)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed