Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50013046
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50436459(CHEMBL2396661)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM330292(US9724352, I-28 | 1-(4-fluorophenyl)-3-(5-(6-((4-(...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562347(CHEMBL4740055)
Affinity DataIC50: 20nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM330294(US9724352, I-32 | Ethyl (5-(6-((4-(methylsulfonyl)...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562348(CHEMBL4784118)
Affinity DataIC50: 24nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562344(CHEMBL4742751)
Affinity DataIC50: 40nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM330258(US9724352, I-22 | 1-(4-(4-methylpiperazine-carbony...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM330293(US9724352, I-30 | 1-ethyl-3-(5-(6-((4-(methylsulfo...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562349(CHEMBL4760391)
Affinity DataIC50: 44nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562346(CHEMBL4791280)
Affinity DataIC50: 51nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM330259(US9724352, I-27 | 5-(6-((4-(methylsulfonyl)piperaz...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562343(CHEMBL4800181)
Affinity DataIC50: 68nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human PI3K p110delta/p85alpha using PIP2 as substrate in presence of ATP measured after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562342(CHEMBL4756074)
Affinity DataIC50: 105nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50562345(CHEMBL4799728)
Affinity DataIC50: 244nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50436459(CHEMBL2396661)
Affinity DataIC50: 383nMAssay Description:Inhibition of human PI3K p110delta/p85alpha using PIP2 as substrate in presence of ATP measured after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 598nMAssay Description:Inhibition of human PI3K p110beta/p85alpha using PIP2 as substrate incubated for 40 mins in presence of ATP measured after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant c-Raf Y340D/Y341D mutant (306 to end residues) using inactive MEK1 as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50436459(CHEMBL2396661)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of human PI3K p110beta/p85alpha using PIP2 as substrate incubated for 40 mins in presence of ATP measured after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length recombinant mTOR in presence of [gamma33P-ATP] by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed